4.8 Article

Discovery and molecular basis of subtype-selective cyclophilin inhibitors

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

A 20/20 view of ANT function in mitochondrial biology and necrotic cell death

Michael J. Bround et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

Article Cardiac & Cardiovascular Systems

Molecular nature and regulation of the mitochondrial permeability transition pore(s), drug target(s) in cardioprotection

Michela Carraro et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2020)

Article Biochemistry & Molecular Biology

Mitochondrial Permeability Uncouples Elevated Autophagy and Lifespan Extension

Ben Zhou et al.

Article Biochemistry & Molecular Biology

F-ATP synthase and the permeability transition pore: fewer doubts, more certainties

Michela Carraro et al.

FEBS LETTERS (2019)

Article Multidisciplinary Sciences

Persistence of the permeability transition pore in human mitochondria devoid of an assembled ATP synthase

Joe Carroll et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biochemical Research Methods

Macromolecular structure determination using X-rays, neutrons and electrons: recent developments in Phenix

Dorothee Liebschner et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2019)

Article Chemistry, Medicinal

Discovery of novel Cyclophilin D inhibitors starting from three dimensional fragments with millimolar potencies

Ulrich Graedler et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2019)

Review Pharmacology & Pharmacy

Mitochondrial Permeability Transition: A Molecular Lesion with Multiple Drug Targets

Thomas Briston et al.

TRENDS IN PHARMACOLOGICAL SCIENCES (2019)

Article Chemistry, Multidisciplinary

A computationally designed binding mode flip leads to a novel class of potent tri-vector cyclophilin inhibitors

Alessio De Simone et al.

CHEMICAL SCIENCE (2019)

Review Cell Biology

Mitochondria and aging: A role for the mitochondrial transition pore?

Mathieu Panel et al.

AGING CELL (2018)

Article Chemistry, Multidisciplinary

Second-generation DNA-templated macrocycle libraries for the discovery of bioactive small molecules

Dmitry L. Usanov et al.

NATURE CHEMISTRY (2018)

Review Biochemistry & Molecular Biology

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases

Niamh M. C. Connolly et al.

CELL DEATH AND DIFFERENTIATION (2018)

Article Biochemistry & Molecular Biology

Discovery of non-peptidic small molecule inhibitors of cyclophilin D as neuroprotective agents in Aβ-induced mitochondrial dysfunction

Insun Park et al.

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN (2017)

Article Chemistry, Medicinal

Discovery of Potent Cyclophilin Inhibitors Based on the Structural Simplification of Sanglifehrin A

Victoria A. Steadman et al.

JOURNAL OF MEDICINAL CHEMISTRY (2017)

Article Multidisciplinary Sciences

Ca2+ ionophores are not suitable for inducing mPTP opening in murine isolated adult cardiac myocytes

Mathieu Panel et al.

SCIENTIFIC REPORTS (2017)

Article Chemistry, Medicinal

Peptidyl-Proline Isomerases (PPlases): Targets for Natural Products and Natural Product-Inspired Compounds

Bryan M. Dunyak et al.

JOURNAL OF MEDICINAL CHEMISTRY (2016)

Article Biochemistry & Molecular Biology

Inhibition of Mcl-1 through covalent modification of a noncatalytic lysine side chain

Gizem Akcay et al.

NATURE CHEMICAL BIOLOGY (2016)

Review Cell Biology

Mitochondrial Permeability Transition: New Findings and Persisting Uncertainties

Valentina Izzo et al.

TRENDS IN CELL BIOLOGY (2016)

Article Chemistry, Medicinal

Identification of a Small Molecule Cyclophilin D Inhibitor for Rescuing Aβ-Mediated Mitochondrial Dysfunction

Koteswara Rao Valasani et al.

ACS MEDICINAL CHEMISTRY LETTERS (2016)

Article Multidisciplinary Sciences

Fragment-based discovery of a new family of non-peptidic small-molecule cyclophilin inhibitors with potent antiviral activities

Abdelhakim Ahmed-Belkacem et al.

NATURE COMMUNICATIONS (2016)

Review Biochemistry & Molecular Biology

Multidomain Peptidyl Prolyl cis/trans Isomerases

Cordelia Schiene-Fischer

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2015)

Review Cardiac & Cardiovascular Systems

Molecular identity of the mitochondrial permeability transition pore and its role in ischemia-reperfusion injury

Giampaolo Morciano et al.

JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2015)

Review Biochemistry & Molecular Biology

Roles of Prolyl Isomerases in RNA-Mediated Gene Expression

Roopa Thapar

BIOMOLECULES (2015)

Review Biochemistry & Molecular Biology

Mitochondrial permeability transition pore is a potential drug target for neurodegeneration

Valasani Koteswara Rao et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2014)

Review Biochemistry & Molecular Biology

Cyclophilin D as a potential target for antioxidants in neurodegeneration: the X-ALD case

Jone Lopez-Erauskin et al.

BIOLOGICAL CHEMISTRY (2013)

Article Neurosciences

Mitochondrial permeability transition pore induces mitochondria injury in Huntington disease

Rodrigo A. Quintanilla et al.

MOLECULAR NEURODEGENERATION (2013)

Review Virology

Cyclophilins as Modulators of Viral Replication

Stephen D. Frausto et al.

VIRUSES-BASEL (2013)

Article Pharmacology & Pharmacy

Prolyl cis/trans isomerase signalling pathways in cancer

Martin Theuerkorn et al.

CURRENT OPINION IN PHARMACOLOGY (2011)

Article Chemistry, Multidisciplinary

Implementation and Evaluation of a Docking-Rescoring Method Using Molecular Footprint Comparisons

Trent E. Balius et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2011)

Article Biochemical Research Methods

Features and development of Coot

P. Emsley et al.

ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY (2010)

Article Biochemistry & Molecular Biology

Structural and Biochemical Characterization of the Human Cyclophilin Family of Peptidyl-Prolyl Isomerases

Tara L. Davis et al.

PLOS BIOLOGY (2010)

Article Biochemistry & Molecular Biology

Isoform-Specific Inhibition of Cyclophilins

Sebastian Daum et al.

BIOCHEMISTRY (2009)

Article Biochemical Research Methods

Use of a Real-Time Fluorescence Monitoring System for High-Throughput Screening for Prolyl Isomerase Inhibitors

Tadashi Mori et al.

JOURNAL OF BIOMOLECULAR SCREENING (2009)

Article Biochemistry & Molecular Biology

Crystal structure of human cyclophilin D in complex with its inhibitor, cyclosporin A at 0.96-Å resolution

Kenji Kajitani et al.

PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2008)

Article Chemistry, Multidisciplinary

Phaser crystallographic software

Airlie J. McCoy et al.

JOURNAL OF APPLIED CRYSTALLOGRAPHY (2007)

Review Physiology

Mitochondrial membrane permeabilization in cell death

Guido Kroemer et al.

PHYSIOLOGICAL REVIEWS (2007)

Article Biochemical Research Methods

A fluorescence polarization-based assay for peptidyl prolyl cis/trans isomerase cyclophilin A

Yaya Liu et al.

ANALYTICAL BIOCHEMISTRY (2006)

Article Biochemical Research Methods

A surface plasmon resonance-based assay for small molecule inhibitors of human cyclophilin A

MA Wear et al.

ANALYTICAL BIOCHEMISTRY (2005)

Article Multidisciplinary Sciences

Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia

AC Schinzel et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemical Research Methods

Crystal engineering yields crystals of cyclophilin D diffracting to 1.7 Å resolution

D Schlatter et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2005)

Article Biochemical Research Methods

PRODRG:: a tool for high-throughput crystallography of protein-ligand complexes

AW Schüttelkopf et al.

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2004)

Article Chemistry, Multidisciplinary

UCSF chimera - A visualization system for exploratory research and analysis

EF Pettersen et al.

JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)