Three new cytotoxic annonaceous acetogenins from the seeds of Annona squamosa

Three new annonaceous acetogenins, annotemoyin L (1), annotemoyin Y (2) and annotemoyin X, (3) were isolated from the seeds of Annona squamosa Linn. Their structures were ascertained by chemical methods and spectral data. The cytotoxic activities of compounds against three multidrug-resistant cancer cell lines were evaluated, and compound 3 exerted strong cytotoxicity against SMMC 7721/ADR (IC50 0.163 mu M), A549/T (IC50 0.064 mu M) and MCF-7/ADR (IC50 0.057 mu M).

Automated summary

Three new annonaceous acetogenins were isolated from the seeds of Annona squamosa Linn., and their structures were determined. Among them, compound 3 exhibited strong cytotoxicity against three multidrug-resistant cancer cell lines.