Journal
MOLECULES
Volume 27, Issue 20, Pages -Publisher
MDPI
DOI: 10.3390/molecules27206798
Keywords
thermosensor; photocaged inducer; photoswitch; genetic code expansion; optogenetics
Funding
- National Research Foundation of Korea [2021R1A4A1021950]
- Pusan National University
- National Research Foundation of Korea [2021R1A4A1021950] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The expression of genes of interest can be controlled by providing external stimuli such as temperature shifts and light irradiation, which trigger structural changes in stimuli-sensitive biomolecules within the cell. Over the past two decades, various groups have reported genetic circuits that manipulate gene expression using natural or engineered stimuli-sensitive modules.
The expression of genes of interest (GOI) can be initiated by providing external stimuli such as temperature shifts and light irradiation. The application of thermal or light stimuli triggers structural changes in stimuli-sensitive biomolecules within the cell, thereby inducing or repressing gene expression. Over the past two decades, several groups have reported genetic circuits that use natural or engineered stimuli-sensitive modules to manipulate gene expression. Here, we summarize versatile strategies of thermosensors and light-driven systems for the conditional expression of GOI in bacterial hosts.
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