Journal
MOLECULES
Volume 27, Issue 20, Pages -Publisher
MDPI
DOI: 10.3390/molecules27206953
Keywords
natural products; Mitsunobu reaction; alkaloids; lignans; polyketides; amino acids; carbohydrates
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The Mitsunobu reaction is an important reaction in organic chemistry with wide synthetic applications. It can convert one functional group to another and change the stereochemical configuration of the products. It plays a significant role in the synthesis of natural products.
The Mitsunobu reaction plays a vital part in organic chemistry due to its wide synthetic applications. It is considered as a significant reaction for the interconversion of one functional group (alcohol) to another (ester) in the presence of oxidizing agents (azodicarboxylates) and reducing agents (phosphines). It is a renowned stereoselective reaction which inverts the stereochemical configuration of end products. One of the most important applications of the Mitsunobu reaction is its role in the synthesis of natural products. This review article will focus on the contribution of the Mitsunobu reaction towards the total synthesis of natural products, highlighting their biological potential during recent years.
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