4.6 Article

Development of Novel Pyridine-Thiazole Hybrid Molecules as Potential Anticancer Agents

Related references

Note: Only part of the references are listed.
Article Pharmacology & Pharmacy

Identification of different side effects between PARP inhibitors and their polypharmacological multi-target rationale

Daranjit Sandhu et al.

Summary: Despite their similar mode of action, the polypharmacology of PARP inhibitors influences their ADR profile.

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2022)

Article Pharmacology & Pharmacy

Potential synthetic lethality for breast cancer: A selective sirtuin 2 inhibitor combined with a multiple kinase inhibitor sorafenib

Hua-Li Wang et al.

Summary: This study found that a highly selective SIRT2 inhibitor, I, combined with sorafenib showed significant synergistic reduction in cell viability of MCF-7 cells. The combination treatment suppressed cell proliferation, migration, arrested cell cycle at G0/G1 phase, and induced apoptosis in MCF-7 cells. In vivo experiments also showed that the combination treatment had stronger tumor growth inhibition compared to single treatments with I or sorafenib alone.

PHARMACOLOGICAL RESEARCH (2022)

Article Chemistry, Medicinal

Novel hybrid pyrrolidinedione-thiazolidinones as potential anticancer agents: Synthesis and biological evaluation

Nataliya Finiuk et al.

Summary: A series of novel pyrrolidinedione-thiazolidinones were synthesized and evaluated for their anticancer potential. The compounds showed high antiproliferative activity and cytotoxicity against various cancer cell lines, while exhibiting low toxicity towards normal human cells. The compounds also demonstrated selective cytotoxicity towards leukemia, lung, breast, cervical, colon carcinoma, and glioblastoma cells. The mechanism of action involved mitochondria-dependent apoptosis and DNA damage in treated cancer cells. These findings suggest that the novel hybrid pyrrolidinedione-thiazolidinones have potential as anticancer agents with reduced toxicity towards normal cells.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2022)

Article Biochemistry & Molecular Biology

Synthesis of novel indole-thiazolidinone hybrid structures as promising scaffold with anticancer potential

Anna Kryshchyshyn-Dylevych et al.

Summary: A series of novel indole-azolidinone hybrids were synthesized and resulted in a compound with high cytotoxicity towards tumor cells and lower toxicity towards non-malignant cells. The compound induced apoptosis and DNA damage in tumor cells, suggesting its potential as a promising anticancer agent for further studies.

BIOORGANIC & MEDICINAL CHEMISTRY (2021)

Article Biochemistry & Molecular Biology

Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1

Kevin Ryan et al.

Summary: Poly-ADP-ribosyltransferases are crucial for DNA repair and cell death, with PARP1 being an important therapeutic target for breast cancer treatment due to its synthetic lethal relationship with breast cancer susceptibility proteins 1 and 2. Talazoparib, among the clinical PARP inhibitors, has been shown to effectively trap PARP1 on damaged DNA and potentially bind and engage TNKS1, a regulator of the Wnt/beta-catenin pathway. The differential selectivity of PARP1 inhibitors is attributed to subtle differences in ligand-binding sites, electrostatic nature of the ligands, protein dynamics, and ligand conformational energetics, providing insights for drug design in Wnt/beta-catenin pathway-related cancers.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Article Pharmacology & Pharmacy

An Open Access Database of Licensed Cancer Drugs

Pan Pantziarka et al.

Summary: Currently, there is no global, unified listing of approved anticancer drugs, but a methodology exists to combine and cleanse relevant data from multiple sources to produce a database specifically for therapeutic antineoplastic purposes, which can be used by researchers as input for further research projects.

FRONTIERS IN PHARMACOLOGY (2021)

Article Multidisciplinary Sciences

Structural basis for allosteric PARP-1 retention on DNA breaks

Levani Zandarashvili et al.

SCIENCE (2020)

Article Biochemistry & Molecular Biology

Evaluation of the Anticancer Activities of Novel Transition Metal Complexes with Berenil and Nitroimidazole

Robert Czarnomysy et al.

MOLECULES (2020)

Review Oncology

Advances in synthetic lethality for cancer therapy: cellular mechanism and clinical translation

Win Topatana et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2020)

Article Pharmacology & Pharmacy

Design, computational studies, synthesis and biological evaluation of thiazole-based molecules as anticancer agents

Anuradha et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2019)

Article Biochemistry & Molecular Biology

A thiazole-derived oridonin analogue exhibits antitumor activity by directly and allosterically inhibiting STAT3

Xiaofei Shen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2019)

Article Chemistry, Medicinal

Synthesis, anticancer activity and mechanism of action of new thiazole derivatives

Temistocles Italo de Santana et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Article Biochemistry & Molecular Biology

Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling

Jayaprakash Periasamy et al.

CELL CHEMICAL BIOLOGY (2018)

Article Biochemistry & Molecular Biology

Structure-based design of new poly (ADP-ribose) polymerase (PARP-1) inhibitors

Navriti Chadha et al.

MOLECULAR DIVERSITY (2017)

Article Chemistry, Organic

Synthesis, Molecular Docking and Anticancer Evaluation of New Arylazothiazoles

Sobhi M. Gomha et al.

CURRENT ORGANIC SYNTHESIS (2017)

Article Chemistry, Multidisciplinary

The Cambridge Structural Database

Colin R. Groom et al.

ACTA CRYSTALLOGRAPHICA SECTION B-STRUCTURAL SCIENCE CRYSTAL ENGINEERING AND MATERIALS (2016)

Article Chemistry, Medicinal

Ethyl 2-((4-Chlorophenyl)amino)thiazole-4-carboxylate and Derivatives Are Potent Inducers of Oct3/4

Xinlai Cheng et al.

JOURNAL OF MEDICINAL CHEMISTRY (2015)

Article Multidisciplinary Sciences

Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells

Sachi Horibata et al.

JOVE-JOURNAL OF VISUALIZED EXPERIMENTS (2015)

Article Chemistry, Multidisciplinary

SHELXT - Integrated space-group and crystal-structure determination

George M. Sheldrick

ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (2015)

Article Chemistry, Multidisciplinary

Crystal structure refinement with SHELXL

George M. Sheldrick

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY (2015)

Article Biochemical Research Methods

Structural basis for the inhibition of poly(ADP-ribose) polymerases 1 and 2 by BMN 673, a potent inhibitor derived from dihydropyridophthalazinone

Mika Aoyagi-Scharber et al.

ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS (2014)

Article Pharmacology & Pharmacy

Dabrafenib: First Global Approval

Anita D. Ballantyne et al.

DRUGS (2013)

Article Biochemistry & Molecular Biology

Structure-guided design of a selective BCL-XL inhibitor

Guillaume Lessene et al.

NATURE CHEMICAL BIOLOGY (2013)

Article Chemistry, Medicinal

Novel poly(ADP-ribose) polymerase-1 inhibitors

Derek Dunn et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Software Review Chemistry, Multidisciplinary

WinGX and ORTEP for Windows: an update

Louis J. Farrugia

JOURNAL OF APPLIED CRYSTALLOGRAPHY (2012)

Review Pharmacology & Pharmacy

Active Targeting Strategies for Anticancer Drug Nanocarriers

Livia Basile et al.

CURRENT DRUG DELIVERY (2012)

Article Multidisciplinary Sciences

Breast Cancer Stem-Like Cells Are Inhibited by a Non-Toxic Aryl Hydrocarbon Receptor Agonist

Gerald J. Prud'homme et al.

PLOS ONE (2010)

Article Biochemical Research Methods

Structure validation in chemical crystallography

Anthony L. Spek

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY (2009)

Review Biochemistry & Molecular Biology

Pharmacokinetics of Biotech Drugs: Peptides, Proteins and Monoclonal Antibodies

Jiunn H. Lin

CURRENT DRUG METABOLISM (2009)

Software Review Chemistry, Multidisciplinary

OLEX2: a complete structure solution, refinement and analysis program

Oleg V. Dolomanov et al.

JOURNAL OF APPLIED CRYSTALLOGRAPHY (2009)

Article Biotechnology & Applied Microbiology

A novel and simple method of screening compounds for interaction with DNA: A validation study

Adel Garas et al.

MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS (2009)

Review Pharmacology & Pharmacy

Molecular Docking Algorithms

Raquel Dias et al.

CURRENT DRUG TARGETS (2008)

Article Chemistry, Medicinal

Synthesis and anticonvulsant activity of some novel 3-aryl amino/amino-4-aryl-5-imino-Δ2-1,2,4-thiadiazoline

Arun Gupta et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2008)

Article Chemistry, Medicinal

An alternative method for the evaluation of docking performance: RSR vs RMSD

Dilmurat Yusuf et al.

JOURNAL OF CHEMICAL INFORMATION AND MODELING (2008)

Article Biochemical Research Methods

A high-throughput soft agar assay for identification of anticancer compound

Steven N. Anderson et al.

JOURNAL OF BIOMOLECULAR SCREENING (2007)

Article Oncology

The NCI60 human tumour cell line anticancer drug screen

Robert H. Shoemaker

NATURE REVIEWS CANCER (2006)

Article Biochemical Research Methods

Clonogenic assay of cells in vitro

Nicolaas A. P. Franken et al.

NATURE PROTOCOLS (2006)

Review Biochemistry & Molecular Biology

Protein-protein interactions and cancer: small molecules going in for the kill

M Arkin

CURRENT OPINION IN CHEMICAL BIOLOGY (2005)