Synthesis and Kinase Inhibitory Potencies of Pyrazolo[3,4-g]isoquinolines

A new series of pyrazolo[3,4-g]isoquinoline derivatives, diversely substituted at the 4- or 8-position, were synthesized. The results of the kinase inhibitory potency study demonstrated that the introduction of a bromine atom at the 8-position was detrimental to Haspin inhibition, while the introduction of an alkyl group at the 4-position led to a modification of the kinase inhibition profiles. Altogether, the results obtained demonstrated that new pyrazolo[3,4-g]isoquinolines represent a novel family of kinase inhibitors with various selectivity profiles.

Automated summary

A new series of pyrazolo[3,4-g]isoquinoline derivatives, diverse in substitution at the 4- or 8-position, were synthesized and evaluated for their kinase inhibitory potency. The results showed that the introduction of a bromine atom at the 8-position had a negative effect on Haspin inhibition, while the introduction of an alkyl group at the 4-position led to a modification of the kinase inhibition profiles. Overall, the new pyrazolo[3,4-g]isoquinolines represent a novel family of kinase inhibitors with various selectivity profiles.