Related references
Note: Only part of the references are listed.AI-based protein structure databases have the potential to accelerate rare diseases research: AlphaFoldDB and the case of IAHSP/Alsin
Matteo Rossi Sebastiano et al.
DRUG DISCOVERY TODAY (2022)
2-Year-Old and 3-Year-Old Italian ALS Patients with Novel ALS2 Mutations: Identification of Key Metabolites in Their Serum and Plasma
Mukesh Gautam et al.
METABOLITES (2022)
Three Simple Properties Explain Protein Stability Change upon Mutation
Octav Caldararu et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2021)
The Role of Vitamin K in Humans: Implication in Aging and Age-Associated Diseases
Daniela-Saveta Popa et al.
ANTIOXIDANTS (2021)
The N-terminal intrinsically disordered region mediates intracellular localization and self-oligomerization of ALS2
Kento Shimakura et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2021)
Highly accurate protein structure prediction for the human proteome
Kathryn Tunyasuvunakool et al.
NATURE (2021)
Vitamin K as a Diet Supplement with Impact in Human Health: Current Evidence in Age-Related Diseases
Dina C. Simes et al.
NUTRIENTS (2020)
ProteinsPlus: interactive analysis of protein-ligand binding interfaces
Katrin Schoening-Stierand et al.
NUCLEIC ACIDS RESEARCH (2020)
Webina: an open-source library and web app that runs AutoDock Vina entirely in the web browser
Yuri Kochnev et al.
BIOINFORMATICS (2020)
Scalable molecular dynamics on CPU and GPU architectures with NAMD
James C. Phillips et al.
JOURNAL OF CHEMICAL PHYSICS (2020)
Performance and Its Limits in Rigid Body Protein-Protein Docking
Israel T. Desta et al.
STRUCTURE (2020)
The Neglected Genes of ALS: Cytoskeletal Dynamics Impact Synaptic Degeneration in ALS
Maria Jose Castellanos-Montiel et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2020)
PrankWeb: a web server for ligand binding site prediction and visualization
Lukas Jendele et al.
NUCLEIC ACIDS RESEARCH (2019)
DrugBank 5.0: a major update to the DrugBank database for 2018
David S. Wishart et al.
NUCLEIC ACIDS RESEARCH (2018)
CABS-flex 2.0: a web server for fast simulations of flexibility of protein structures
Aleksander Kuriata et al.
NUCLEIC ACIDS RESEARCH (2018)
CASTp 3.0: computed atlas of surface topography of proteins
Wei Tian et al.
NUCLEIC ACIDS RESEARCH (2018)
Rab5 and Alsin regulate stress-activated cytoprotective signaling on mitochondria
FoSheng Hsu et al.
ELIFE (2018)
Altered oligomeric states in pathogenic ALS2 variants associated with juvenile motor neuron diseases cause loss of ALS2-mediated endosomal function
Kai Sato et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2018)
The ClusPro web server for protein-protein docking
Dima Kozakov et al.
NATURE PROTOCOLS (2017)
Absence of alsin function leads to corticospinal motor neuron vulnerability via novel disease mechanisms
Mukesh Gautam et al.
HUMAN MOLECULAR GENETICS (2016)
Mitochondrial fission is an acute and adaptive response in injured motor neurons
Sumiko Kiryu-Seo et al.
SCIENTIFIC REPORTS (2016)
QwikMD - Integrative Molecular Dynamics Toolkit for Novices and Experts
Joao V. Ribeiro et al.
SCIENTIFIC REPORTS (2016)
IBS: an illustrator for the presentation and visualization of biological sequences
Wenzhong Liu et al.
BIOINFORMATICS (2015)
ZINC 15-Ligand Discovery for Everyone
Teague Sterling et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2015)
ZDOCK server: interactive docking prediction of protein-protein complexes and symmetric multimers
Brian G. Pierce et al.
BIOINFORMATICS (2014)
WEBnm@ v2.0: Web server and services for comparing protein flexibility
Sandhya P. Tiwari et al.
BMC BIOINFORMATICS (2014)
Small-molecule inhibitor starting points learned from protein-protein interaction inhibitor structure
David Ryan Koes et al.
BIOINFORMATICS (2012)
Physiological Roles of Mitochondrial Reactive Oxygen Species
Laura A. Sena et al.
MOLECULAR CELL (2012)
Defective relocalization of ALS2/alsin missense mutants to Rac1-induced macropinosomes accounts for loss of their cellular function and leads to disturbed amphisome formation
Asako Otomo et al.
FEBS LETTERS (2011)
Human Vitamin K 2,3-Epoxide Reductase Complex Subunit 1-like 1 (VKORC1L1) Mediates Vitamin K-dependent Intracellular Antioxidant Function
Philipp Westhofen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Molecular pathways of motor neuron injury in amyotrophic lateral sclerosis
Laura Ferraiuolo et al.
NATURE REVIEWS NEUROLOGY (2011)
Molecular fields in drug discovery: getting old or reaching maturity?
Simon Cross et al.
DRUG DISCOVERY TODAY (2010)
An interrupted beta-propeller and protein disorder: structural bioinformatics insights into the N-terminus of alsin
Dinesh C. Soares et al.
JOURNAL OF MOLECULAR MODELING (2009)
Mitofusin 2 tethers endoplasmic reticulum to mitochondria
Olga Martins de Brito et al.
NATURE (2008)
Alsin and the molecular pathways of amyotrophic lateral sclerosis
Jayanth Chandran et al.
MOLECULAR NEUROBIOLOGY (2007)
The Rab5 activator ALS2/alsin acts as a novel Rac1 effector through Rac1-activated endocytosis
Ryota Kunita et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Mice deficient in the Rab5 guanine nucleotide exchange factor ALS2/alsin exhibit age-dependent neurological deficits and altered endosome trafficking
S Hadano et al.
HUMAN MOLECULAR GENETICS (2006)
Homo-oligomerization of ALS2 through its unique carboxyl-terminal regions is essential for the ALS2-associated Rab5 guanine nucleotide exchange activity and its regulatory function on endosome trafficking
R Kunita et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5
A Delprato et al.
CELL (2004)
Alsin is a Rab5 and Rac1 guanine nucleotide exchange factor
JD Topp et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
UCSF chimera - A visualization system for exploratory research and analysis
EF Pettersen et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2004)
Improved protein-ligand docking using GOLD
ML Verdonk et al.
PROTEINS-STRUCTURE FUNCTION AND GENETICS (2003)
ALS2, a novel guanine nucleotide exchange factor for the small GTPase Rab5, is implicated in endosomal dynamics
A Otomo et al.
HUMAN MOLECULAR GENETICS (2003)
Infantile ascending hereditary spastic paralysis (IAHSP) - Clinical features in 11 families
G Lesca et al.
NEUROLOGY (2003)
Infantile-onset ascending hereditary spastic paralysis is associated with mutations in the alsin gene
E Eymard-Pierre et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2002)
Inverse correlation between the changes of lumbar bone mineral density and serum undercarboxylated osteocalcin after vitamin K2 (menatetrenone) treatment in children treated with glucocorticoid and alfacalcidol
T Inoue et al.
ENDOCRINE JOURNAL (2001)
Share Paper
