4.6 Article

Nipecotic Acid Derivatives as Potent Agents against Neurodegeneration: A Preliminary Study

Related references

Note: Only part of the references are listed.
Article Chemistry, Medicinal

Gabapentin Antioxidant Derivatives with Anti-Inflammatory and Neuroprotective Potency

Georgios Papagiouvannis et al.

Summary: The aim of this study is to investigate the antioxidant and anti-inflammatory potency of novel gabapentin derivatives for neuroprotection against Alzheimer's disease (AD). The designed compounds showed potential as multi-targeting molecules, affecting various biochemical pathways associated with neurodegeneration, thus offering a promising approach for the development of effective drugs against AD.

LETTERS IN DRUG DESIGN & DISCOVERY (2022)

Article Biochemistry & Molecular Biology

Enhancement of the Anti-Inflammatory Activity of NSAIDs by Their Conjugation with 3,4,5-Trimethoxybenzyl Alcohol

Paraskevi Tziona et al.

Summary: The synthesis of derivatives of three nonspecific COX-1 and COX-2 inhibitors, ibuprofen, ketoprofen, naproxen, with enhanced anti-inflammatory activity, has been presented. The novel compounds demonstrated stronger inhibition of COX-2 and higher effectiveness in reducing inflammation compared to the parent drugs.

MOLECULES (2022)

Article Biochemistry & Molecular Biology

Attenuation of Scopolamine-Induced Amnesia via Cholinergic Modulation in Mice by Synthetic Curcumin Analogs

Haya Hussain et al.

Summary: In this study, six curcumin analogs were synthesized and evaluated for their potential to inhibit cholinesterase. The synthesized compounds showed promising results in improving memory functions in mice models. Further research is needed to determine their exact mechanism of action.

MOLECULES (2022)

Article Plant Sciences

In vitro antioxidant, anticholinesterase, tyrosinase activity studies, and LC-MS/MS simultaneous determination of 37 bioactive compounds in Indigofera heterantha

Zain Ullah et al.

Summary: The extracts of Indigofera heterantha, a flowering plant in the Himalayas known as Indigo of Himalayan, exhibited antioxidant and enzyme inhibition activities. The ethyl acetate and n-hexane extracts showed the best radical scavenging and antioxidant activities, while the methanol extract demonstrated moderate activity. The plant contains phenolic compounds that contribute to its biological activities. It has the potential to be used as a functional food ingredient in the food industry and pharmaceuticals.

SOUTH AFRICAN JOURNAL OF BOTANY (2022)

Review Chemistry, Medicinal

A Review on Vitamin E Natural Analogues and on the Design of Synthetic Vitamin E Derivatives as Cytoprotective Agents

Panagiotis Theodosis-Nobelos et al.

Summary: This review outlines the differences in metabolism and excretion of multiple forms of Vitamin E and discusses the antioxidant and non-antioxidant properties of Vitamin E. Additionally, it explores how synthetic tocopherol and trolox derivatives, designed as multitarget directed compounds, can produce improved antioxidants for combating cancer, cardiovascular, and neurodegenerative disorders.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2021)

Review Chemistry, Medicinal

Multi-target Directed Compounds with Antioxidant and/or Anti-inflammatory Properties as Potent Agents for Alzheimer's Disease

Georgios Papagiouvannis et al.

Summary: Researchers have been investigating the potential of multi-target directed compounds with antioxidant and/or anti-inflammatory properties for the treatment of Alzheimer's Disease, which has only symptomatic efficacy with current treatments.Various novel compounds with these properties have shown promising results in the treatment of neurodegenerative disorders.

MEDICINAL CHEMISTRY (2021)

Review Neurosciences

Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease

Gabriella Marucci et al.

Summary: Alzheimer's disease is characterized by cognitive decline and behavioral manifestations, with the most common treatment being cholinesterase inhibitors. Despite their limited efficacy and gastrointestinal side effects, ChE-Is remain a pharmacotherapeutic resource for AD treatment. Investigating combinations with other drug classes may offer renewed interest in the use of ChE-Is for adult-onset dementia disorders.

NEUROPHARMACOLOGY (2021)

Article Immunology

Elevated β-secretase 1 expression mediates CD4+ T cell dysfunction via PGE2 signalling in Alzheimer's disease

Linbin Dai et al.

Summary: In AD patients and 5xFAD transgenic mice, CD4(+) T cells exhibit elevated levels of beta-secretase 1 (BACE1), which promotes T-cell activation and immune responses by modulating prostaglandin E2 (PGE2) synthesis. Administration of peripheral PGE2 signalling antagonists partially ameliorates CD4(+) T cell overactivation and AD pathology in 5xFAD mice. Overall, BACE1 may play a potential role in mediating CD4(+) T-cell dysfunction in AD.

BRAIN BEHAVIOR AND IMMUNITY (2021)

Article Biochemistry & Molecular Biology

In Vitro Antioxidant and Anti-Glycation Activity of Resveratrol and Its Novel Triester with Trolox

Sebastiano Intagliata et al.

Summary: A novel resveratrol triester derivative, RSVTR, was synthesized by combining resveratrol with trolox, exhibiting improved anti-glycation activity compared to resveratrol. RSVTR showed good chemical stability under various pHs and temperatures, with the greatest stability observed at pH 7.2 and 5 degrees C. The enhanced ability to inhibit the glycation process was attributed to RSVTR's better interaction with albumin due to increased topological polar surface area values and H-bond acceptor numbers.

ANTIOXIDANTS (2021)

Article Biochemistry & Molecular Biology

Neuroprotective Potential of Synthetic Mono-Carbonyl Curcumin Analogs Assessed by Molecular Docking Studies

Haya Hussain et al.

Summary: This study synthesized five mono-carbonyl curcumin analogs and found that two of them significantly inhibited cholinesterases in vivo and improved memory in mice. Molecular docking study confirmed the mechanism of cholinesterase inhibition for these compounds.

MOLECULES (2021)

Article Biochemistry & Molecular Biology

Antioxidant Serine-(NSAID) Hybrids with Anti-Inflammatory and Hypolipidemic Potency

Panagiotis Theodosis-Nobelos et al.

Summary: A series of L-serine amides of antioxidant acids were synthesized, with Trolox derivatives containing ibuprofen and ketoprofen showing the most potent inhibition of lipid peroxidation. These compounds also exhibited moderate inhibition of soybean lipoxygenase and significant decrease in lipidemic indices in Triton-induced hyperlipidemic rats, similar to the effects of simvastatin. The designed compounds may have potential therapeutic applications for inflammatory and degenerative conditions.

MOLECULES (2021)

Article Biochemistry & Molecular Biology

Active Anti-Inflammatory and Hypolipidemic Derivatives of Lorazepam

Panagiotis Theodosis-Nobelos et al.

MOLECULES (2019)

Review Geriatrics & Gerontology

Microglia in Alzheimer Disease: Well-Known Targets and New Opportunities

Anne-Laure Hemonnot et al.

FRONTIERS IN AGING NEUROSCIENCE (2019)

Article Chemistry, Medicinal

Recent advances in the search for novel 5-lipoxygenase inhibitors for the treatment of asthma

Ferdinando Bruno et al.

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2018)

Review Pharmacology & Pharmacy

Safer anti-inflammatory therapy through dual COX-2/5-LOX inhibitors: A structure-based approach

Jaismy P. Jacob et al.

EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES (2018)

Review Neurosciences

The Association of Tau With Mitochondrial Dysfunction in Alzheimer's Disease

Ying Cheng et al.

FRONTIERS IN NEUROSCIENCE (2018)

Review Biochemistry & Molecular Biology

Oxidative stress and the amyloid beta peptide in Alzheimer's disease

C. Cheignon et al.

REDOX BIOLOGY (2018)

Review Biochemistry & Molecular Biology

Cholinergic modulation of the hippocampal region and memory fuction

Juhee Haam et al.

JOURNAL OF NEUROCHEMISTRY (2017)

Article Chemistry, Medicinal

Anti-inflammatory and Hypolipidemic Effect of Novel Conjugates with Trolox and Other Antioxidant Acids

Panagiotis Theodosis-Nobelos et al.

MEDICINAL CHEMISTRY (2017)

Article Chemistry, Medicinal

Dual antioxidant structures with potent anti-inflammatory, hypolipidemic and cytoprotective properties

Panagiotis Theodosis-Nobelos et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2017)

Article Biochemistry & Molecular Biology

The Lipoxygenases: Their Regulation and Implication in Alzheimer's Disease

Grzegorz A. Czapski et al.

NEUROCHEMICAL RESEARCH (2016)

Review Pharmacology & Pharmacy

A review on Alzheimer's disease pathophysiology and its management: an update

Anil Kumar et al.

PHARMACOLOGICAL REPORTS (2015)

Review Neurosciences

Tau Oligomers: The Toxic Player at Synapses in Alzheimer's Disease

Marcos J. Guerrero-Munoz et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2015)

Review Neurosciences

Oxidative stress in Alzheimer's disease

Zhichun Chen et al.

NEUROSCIENCE BULLETIN (2014)

Review Cell Biology

Tau protein phosphatases in Alzheimer's disease: The leading role of PP2A

Ludovic Martin et al.

AGEING RESEARCH REVIEWS (2013)

Article Behavioral Sciences

Neuroprotective effect of sinapic acid in a mouse model of amyloid β1-42 protein-induced Alzheimer's disease

Hyung Eun Lee et al.

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR (2012)

Article Cardiac & Cardiovascular Systems

Atrial fibrillation is independently associated with senile, vascular, and Alzheimer's dementia

T. Jared Bunch et al.

HEART RHYTHM (2010)

Review Medicine, General & Internal

MECHANISMS OF DISEASE Alzheimer's Disease

Henry W. Querfurth et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Biochemistry & Molecular Biology

5-Lipoxygenase gene disruption reduces amyloid-β pathology in a mouse model of Alzheimer's disease

Omidreza Firuzi et al.

FASEB JOURNAL (2008)

Article Biochemistry & Molecular Biology

New analogues of butylated hydroxytoluene as anti-inflammatory and antioxidant agents

George N. Ziakas et al.

BIOORGANIC & MEDICINAL CHEMISTRY (2006)

Article Multidisciplinary Sciences

Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer's mice

T Wyss-Coray et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)

Article Biochemistry & Molecular Biology

Antiinflammatory activity of cinnamic acid esters

ME Godoy et al.

MOLECULES (2000)