☆ 4.6 Article

Neuroprotective Effect of Polyphenol Extracts from Terminalia chebula Retz. against Cerebral Ischemia-Reperfusion Injury

MOLECULES (2022)

Related references

Note: Only part of the references are listed.

Review Neurosciences

Research progress of natural products for the treatment of ischemic stroke

Jiaxin Li et al.

Summary: Stroke is a major cause of death and disability globally, and its incidence rate is increasing. Natural products have been used in traditional medicine and show potential in the treatment of stroke. This article reviews the neuroprotective effects of 33 natural compounds, some of which have potential as clinical treatments for ischemic stroke.

JOURNAL OF INTEGRATIVE NEUROSCIENCE (2022)

Add to Collection

Article Pharmacology & Pharmacy

Rutin protects hemorrhagic stroke development via supressing oxidative stress and inflammatory events in a zebrafish model

Anil Kumar Rana et al.

Summary: Rutin treatment protects against intracerebral hemorrhagic stroke in a zebrafish model by suppressing oxidative stress and inflammatory events.

EUROPEAN JOURNAL OF PHARMACOLOGY (2022)

Add to Collection

Article Oncology

Preserving mitochondrial function by inhibiting GRP75 ameliorates neuron injury under ischemic stroke

Bin Wen et al.

Summary: Ischemic stroke is closely related to mitochondrial dysfunction, with mitochondrial calcium overload playing a key role in the pathophysiological process. Inhibiting GRP75 can effectively ameliorate mitochondrial function and potentially provide evidence for translational studies of ischemic diseases.

MOLECULAR MEDICINE REPORTS (2022)

Add to Collection

Review Neurosciences

Neuronal Death Mechanisms and Therapeutic Strategy in Ischemic Stroke

Rui Mao et al.

Summary: The mechanisms of neuronal death following ischemic stroke involve various pathological events, including excitotoxicity, oxidative stress, and inflammatory responses. Understanding the mechanisms of these events is critical for developing new neuroprotective strategies, and some progress has been made in pharmacological research.

NEUROSCIENCE BULLETIN (2022)

Add to Collection

Article Biochemistry & Molecular Biology

Oxidative Stress in Ischemia/Reperfusion Injuries following Acute Ischemic Stroke

Anamaria Jurcau et al.

Summary: This article discusses the application of recanalization therapy in the treatment of acute ischemic stroke and the potential ischemia/reperfusion injuries it may cause. Oxidative stress and mitochondrial dysfunction have been identified as significant factors in the pathogenesis of these injuries, but clinical studies targeting oxidative pathways have mostly been unsuccessful.

BIOMEDICINES (2022)

Add to Collection

Article Neurosciences

Non-mitogenic fibroblast growth factor 1 protects against ischemic stroke by regulating microglia/macrophage polarization through Nrf2 and NF-ΚB pathways

Confidence Dordoe et al.

Summary: This study evaluated the neuroprotective effects of nmFGF1 on microglia in a mouse stroke model and determined its mechanism of action. The findings showed that nmFGF1 reduced infarct size and improved neurological deficits by regulating the secretion of inflammatory and anti-inflammatory cytokines. In vitro experiments demonstrated that nmFGF1 modulated the expression of these cytokines under oxygen-glucose deprivation and lipopolysaccharide stimulation. Furthermore, nmFGF1 activated the Nrf2 pathway and inhibited the NF-kappa B pathway, leading to a reduction in neuroinflammation. These results suggest that nmFGF1 has the potential to be used as a therapeutic agent for ischemic stroke.

NEUROPHARMACOLOGY (2022)

Add to Collection

Review Neurosciences

Neuroprotective effects of natural compounds on neurotoxin-induced oxidative stress and cell apoptosis

Bo Chen et al.

Summary: Oxidative stress plays a significant role in neurodegeneration, and natural compounds have potential anti-oxidation effects by modulating multiple signaling pathways and preventing mitochondria-dependent apoptosis pathways, exerting neuroprotective effects.

NUTRITIONAL NEUROSCIENCE (2022)

Add to Collection

Review Endocrinology & Metabolism

Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage

Takahiko Imai et al.

Summary: Intracranial hemorrhage (ICH) is a devastating disease categorized into primary brain injury (PBI) and secondary brain injury (SBI), with oxidative and inflammatory stresses playing central roles. Nrf2 activators have the therapeutic potential in treating ICH patients by up-regulating anti-oxidative enzymes in the brain.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2021)

Add to Collection

Article Plant Sciences

Protective effect of Terminalia chebula Retz. extract against Aβ aggregation and Aβ-induced toxicity in Caenorhabditis elegans

Longhe Zhao et al.

Summary: The study demonstrates that Terminalia chebula extract can protect C.elegans against A beta 1-42-induced toxicity, inhibit A beta 142 aggregation, and delay A beta-induced paralysis through the activation of the DAF-16/HSF-1/Hsp-16.2 pathway.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Add to Collection

Article Biochemistry & Molecular Biology

In vivo dynamics of acidosis and oxidative stress in the acute phase of an ischemic stroke in a rodent model

Ilya Kelmanson et al.

Summary: Ischemic cerebral stroke is a major cause of death and disability in humans, but the molecular processes underlying its development are poorly understood. The study recorded the dynamics of intracellular pH and H2O2 during I/R and found a significant difference in the metabolic processes between in vivo and cultured neuron models. The findings highlight the limitations of cell culture as a predictor of metabolic events in vivo.

REDOX BIOLOGY (2021)

Add to Collection

Article Plant Sciences

Multiple in vitro biological effects of phenolic compounds from Terminalia chebula var. tomentella

Xiao-Rui Zhang et al.

Summary: The main active ingredients of Terminalia chebula fruits are lignans and hydrolyzed tannins, which are responsible for traditional treatment of sore throat and cough. These compounds also show potential hypoglycemic activity, supporting the ethno-pharmacological uses of the fruit in treating diabetes in Tibetan medicine.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

The Nrf2 Pathway in Ischemic Stroke: A Review

Marcelo Farina et al.

Summary: Ischemic stroke, the sudden loss of blood flow in specific area(s) of the brain, is a leading cause of permanent disability and death worldwide. The only approved pharmacological treatment, intravenous thrombolysis with recombinant tissue plasminogen activator, has limitations and does not address the complex oxidative events in the ischemic cascade. The transcription factor Nrf2 has been identified as a potential target to mitigate oxidative events and research has shown its protective role in experimental models of ischemic stroke.

MOLECULES (2021)

Add to Collection

Review Cell Biology

Role of Polyphenols as Antioxidant Supplementation in Ischemic Stroke

Yuan Zhou et al.

Summary: Stroke is the second most common cause of death globally and the leading cause of death in China. Oxidative stress plays a crucial role in the pathogenesis of cerebral ischemia injury, making antioxidants a potential therapeutic target for ischemic stroke. Some polyphenols have been found to have strong antioxidant effects on reactive oxygen species generation and oxidative stress after ischemic stroke.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2021)

Add to Collection

Review Geriatrics & Gerontology

Microglial Polarization: Novel Therapeutic Strategy against Ischemic Stroke

Yimeng Xue et al.

Summary: Ischemic stroke, the second leading cause of death and disability globally, is found to be associated with immunity and inflammation in its pathobiology. The focus has shifted towards promoting microglial polarization towards the M2 phenotype after stroke, as microglia play a crucial role in the nervous system defense.

AGING AND DISEASE (2021)

Add to Collection

Article Nutrition & Dietetics

Polysaccharides from Opuntia milpa alta alleviate alloxan-induced INS-1 cells apoptosis via reducing oxidative stress and upregulating Nrf2 expression

Weiling Li et al.

NUTRITION RESEARCH (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Inhibition of PDE4 protects neurons against oxygen-glucose deprivation-induced endoplasmic reticulum stress through activation of the Nrf-2/HO-1 pathway

Bingtian Xu et al.

REDOX BIOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Restoration of L-OPA1 alleviates acute ischemic stroke injury in rats via inhibiting neuronal apoptosis and preserving mitochondrial function

Yongxing Lai et al.

REDOX BIOLOGY (2020)

Add to Collection

Review Chemistry, Medicinal

Fruits of Terminalia chebula Retz.: A review on traditional uses, bioactive chemical constituents and pharmacological activities

Manisha Nigam et al.

PHYTOTHERAPY RESEARCH (2020)

Add to Collection

Article Neurosciences

Corilagin ameliorates sleep deprivation-induced memory impairments by inhibiting NOX2 and activating Nrf2

Wenjun Wang et al.

BRAIN RESEARCH BULLETIN (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Baicalin combats glutamate excitotoxicity via protecting glutamine synthetase from ROS-induced 20S proteasomal degradation

Xianrui Song et al.

REDOX BIOLOGY (2020)

Add to Collection

Article Agriculture, Dairy & Animal Science

In Vitro Antibacterial Evaluation of Terminalia chebula as an Alternative of Antibiotics against Bovine Subclinical Mastitis

Mukesh N. Kher et al.

ANIMAL BIOTECHNOLOGY (2019)

Add to Collection

Article Medicine, Research & Experimental

Therapeutic effects of melatonin on cerebral ischemia reperfusion injury: Role of Yap-OPA1 signaling pathway and mitochondrial fusion

Na Wei et al.

BIOMEDICINE & PHARMACOTHERAPY (2019)

Add to Collection

Review Biochemistry & Molecular Biology

Apoptosis regulation in the penumbra after ischemic stroke: expression of pro- and antiapoptotic proteins

Anatoly B. Uzdensky

APOPTOSIS (2019)

Add to Collection

Article Cell Biology

Nrf2/ARE pathway inhibits ROS-induced NLRP3 inflammasome activation in BV2 cells after cerebral ischemia reperfusion

Xiujian Xu et al.

INFLAMMATION RESEARCH (2018)

Add to Collection

Article Medicine, Research & Experimental

Cassia grandis fruit extract reduces the blood glucose level in alloxan-induced diabetic rats

Ariadna Lafourcade Prada et al.

BIOMEDICINE & PHARMACOTHERAPY (2018)

Add to Collection

Article Integrative & Complementary Medicine

Terminalia chebula extract prevents scopolamine-induced amnesia via cholinergic modulation and anti-oxidative effects in mice

Min-Soo Kim et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2018)

Add to Collection

Article Pharmacology & Pharmacy

Effects of corilagin on alleviating cholestasis via farnesoid X receptor-associated pathways in vitro and in vivo

Fan Yang et al.

BRITISH JOURNAL OF PHARMACOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Pathogenesis of cardiac ischemia reperfusion injury is associated with CK2α-disturbed mitochondrial homeostasis via suppression of FUNDC1-related mitophagy

Hao Zhou et al.

CELL DEATH AND DIFFERENTIATION (2018)

Add to Collection

Article Pharmacology & Pharmacy

Tannins from Terminalia chebula fruits attenuates GABA antagonist-induced anxiety-like behaviour via modulation of neurotransmitters

Yadavalli Chandrasekhar et al.

JOURNAL OF PHARMACY AND PHARMACOLOGY (2018)

Add to Collection

Article Clinical Neurology

The High Cost of Stroke and Stroke Cytoprotection Research

Paul A. Lapchak et al.

TRANSLATIONAL STROKE RESEARCH (2017)

Add to Collection

Article Cell Biology

Edaravone protects against oxygen-glucose-serum deprivation/restoration-induced apoptosis in spinal cord astrocytes by inhibiting integrated stress response

Bin Dai et al.

NEURAL REGENERATION RESEARCH (2017)

Add to Collection

Article Neurosciences

TRANSCRIPTOMIC ANALYSIS REVEALS DIFFERENTIAL ACTIVATION OF MICROGLIAL GENES AFTER ISCHEMIC STROKE IN MICE

Akbar Khan et al.

NEUROSCIENCE (2017)

Add to Collection

Article Chemistry, Medicinal

Protective Role of Corilagin on A25-35-Induced Neurotoxicity: Suppression of NF-B Signaling Pathway

Kumju Youn et al.

JOURNAL OF MEDICINAL FOOD (2016)

Add to Collection

Article Biochemistry & Molecular Biology

Nrf2 regulates ROS production by mitochondria and NADPH oxidase

Stjepana Kovac et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2015)

Add to Collection

Article Cell Biology

Curcumin pretreatment and post-treatment both improve the antioxidative ability of neurons with oxygen-glucose deprivation

Jing-xian Wu et al.

NEURAL REGENERATION RESEARCH (2015)

Add to Collection

Article Gastroenterology & Hepatology

Anti-inflammatory and anti-oxidative effects of corilagin in a rat model of acute cholestasis

Feng Jin et al.

BMC GASTROENTEROLOGY (2013)

Add to Collection

Article Neurosciences

Oxidative Stress and Pathophysiology of Ischemic Stroke: Novel Therapeutic Opportunities

Ramon Rodrigo et al.

CNS & Neurological Disorders-Drug Targets (2013)

Add to Collection

Article Biochemistry & Molecular Biology

Extract from Terminalia chebula Seeds Protect Against Experimental Ischemic Neuronal Damage Via Maintaining SODs and BDNF Levels

Joon Ha Park et al.

NEUROCHEMICAL RESEARCH (2011)

Add to Collection

Article Pharmacology & Pharmacy

Antioxidant effects of aqueous extract of Terminalia chebula in vivo and in vitro

HS Lee et al.

BIOLOGICAL & PHARMACEUTICAL BULLETIN (2005)

Add to Collection

Review Medicine, Research & Experimental

iNOS-mediated nitric oxide production and its regulation

F Aktan

LIFE SCIENCES (2004)

Add to Collection

Article Neurosciences

Regional difference in susceptibility to lipopolysaccharide-induced neurotoxicity in the rat brain: Role of microglia

WG Kim et al.

JOURNAL OF NEUROSCIENCE (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.