Journal
MOLECULES
Volume 27, Issue 19, Pages -Publisher
MDPI
DOI: 10.3390/molecules27196430
Keywords
cyclotides; drug design; backbone cyclized polypeptides; protein-protein interactions; Cys-rich peptides
Funding
- National Institutes of Health [R35-GM132072]
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This review provides an overview of the properties of cyclotides and their potential for developing novel peptide-based therapeutics. Cyclotides, with their cell-permeability properties, have shown great promise for targeting biomolecular interactions. Molecular techniques employing the cyclotide scaffold have been highly effective for selecting bioactive cyclotides.
This review provides an overview of the properties of cyclotides and their potential for developing novel peptide-based therapeutics. The selective disruption of protein-protein interactions remains challenging, as the interacting surfaces are relatively large and flat. However, highly constrained polypeptide-based molecular frameworks with cell-permeability properties, such as the cyclotide scaffold, have shown great promise for targeting those biomolecular interactions. The use of molecular techniques, such as epitope grafting and molecular evolution employing the cyclotide scaffold, has shown to be highly effective for selecting bioactive cyclotides.
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