Journal
MOLECULES
Volume 27, Issue 19, Pages -Publisher
MDPI
DOI: 10.3390/molecules27196592
Keywords
Australian indigenous plant; hydroxycyclohexenone; flavonoids; anti-inflammatory; nitric oxide (NO); nuclear factor kappa B (NF-kappa B)
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In this study, a new anti-inflammatory compound, tristaenone A (1), was discovered from the leaves of Tristaniopsis laurina. It showed significant inhibition of inflammatory cytokine production in cells, indicating its potential as an anti-inflammatory agent.
Inspired by ethnopharmacological knowledge, we conducted a bioassay-guided fractionation of the leaves of Tristaniopsis laurina which led to the discovery of a new anti-inflammatory compound, tristaenone A (1). The structure was elucidated by detailed spectroscopic data analysis, and the absolute configuration was established using X-ray crystallography analysis. Tristaenone A (1) suppressed LPS and IFN-gamma-induced NO, TNF-alpha and IL-6 production in RAW 264.7 cells with IC50 values of 37.58 +/- 2.45 mu M, 80.6 +/- 5.82 mu M and 125.65 +/- 0.34 mu M, respectively. It also inhibited NF-kappa B nuclear translocation by 52.93 +/- 14.14% at a concentration of 31.85 mu M.
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