Placental Therapeutic Targets and Nanodelivery Systems

Pregnancy complications affect millions of women each year. Some of these diseases have high morbidity and mortality such as preeclampsia. At present, there is no safe and effective treatment for pregnancy complications, so it is still a difficult clinical problem. As many pregnancy complications are closely related to placental dysplasia, placenta-specific therapy, as an important method, is expected to be a safe, effective, and specific therapeutic strategy. This review explains in detail the placenta physiological structure, characteristics, and action mechanism of some biomolecules and signaling pathways that play roles in normal development and disorders of the development of the placenta, and how to use these biomolecules as therapeutic targets when the placenta disorder causes disease, combining the latest progress in the field of nanodelivery systems, so as to lay a foundation for the development of placenta-specific therapy of pregnancy complications.

Automated summary

Pregnancy complications have a significant impact on millions of women each year, but there is currently no safe and effective treatment available. Placenta-specific therapy, which targets abnormal placental development using biomolecules and signaling pathways, shows promise as a safe and effective therapeutic strategy. This review provides a detailed explanation of the physiological structure and characteristics of the placenta, as well as the mechanisms of biomolecules and signaling pathways involved in normal and abnormal placental development. It also discusses how these biomolecules can be used as therapeutic targets and explores the potential of nanodelivery systems in placenta-specific therapy.