The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases

Despite annual increases in the incidence and prevalence of neurodegenerative diseases, there is a lack of effective treatment strategies. An increasing number of E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) have been observed to participate in the pathogenesis mechanisms of neurodegenerative diseases, on the basis of which we conducted a systematic literature review of the studies. This review will help to explore promising therapeutic targets from highly dynamic ubiquitination modification processes.

Automated summary

Despite the increasing incidence and prevalence of neurodegenerative diseases, effective treatment strategies are lacking. This systematic literature review explores the involvement of E3 ubiquitin ligases and deubiquitinating enzymes in the pathogenesis mechanisms of these diseases, aiming to identify promising therapeutic targets.