4.6 Article

Senegenin Rescues PC12 Cells with Oxidative Damage Through Inhibition of Ferroptosis

Related references

Note: Only part of the references are listed.
Article Neurosciences

A direct interaction between RhoGDIα/Tau alleviates hyperphosphorylation of Tau in Alzheimer's disease and vascular dementia

Heping Zhang et al.

Summary: RhoGDI alpha interacts with Tau in Alzheimer's disease and vascular dementia, affecting Tau phosphorylation and apoptosis. Overexpression of RhoGDI alpha can inhibit the generation of NFTs and delay the progress of these two types of dementia.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2023)

Article Clinical Neurology

Senegenin Inhibits Aβ1-42-Induced PC12 Cells Apoptosis and Oxidative Stress via Activation of the PI3K/Akt Signaling Pathway

Xing Ren et al.

Summary: Sen effectively inhibits apoptosis and oxidative stress in A beta(1-42)-induced PC12 cells by activating the PI3K/Akt signaling pathway, regulating the Bcl-2/Bax ratio, and exerting antioxidant effects.

NEUROPSYCHIATRIC DISEASE AND TREATMENT (2022)

Review Cell Biology

Ferroptosis: a cell death connecting oxidative stress, inflammation and cardiovascular diseases

Yi Yu et al.

Summary: Ferroptosis is a newly identified iron-dependent cell death mechanism that differs from other cell death pathways, characterized by lipid peroxidation and accumulation of redox-active iron. Studies suggest that ferroptosis plays a crucial role in various cardiovascular diseases, and targeting ferroptosis may present a novel therapeutic approach in treating these conditions.

CELL DEATH DISCOVERY (2021)

Review Cell Biology

Ferroptosis: past, present and future

Jie Li et al.

CELL DEATH & DISEASE (2020)

Review Plant Sciences

Polygala tenuifolia: a source for anti-Alzheimer's disease drugs

Xinxin Deng et al.

PHARMACEUTICAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Role of Mitochondria in Ferroptosis

Minghui Gao et al.

MOLECULAR CELL (2019)

Article Neurosciences

Ferroptosis and Its Role in Diverse Brain Diseases

Abigail Weiland et al.

MOLECULAR NEUROBIOLOGY (2019)

Review Pathology

Plaque formation and the intraneuronal accumulation of β-amyloid in Alzheimer's disease

Reisuke H. Takahashi et al.

PATHOLOGY INTERNATIONAL (2017)

Article Biochemistry & Molecular Biology

PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals

Sally E. Wenzel et al.

Review Biochemistry & Molecular Biology

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Brent R. Stockwell et al.

Article Integrative & Complementary Medicine

The neuritogenic and neuroprotective potential of senegenin against Aβ-induced neurotoxicity in PC 12 cells

Robert Jesky et al.

BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE (2016)

Article Biochemistry & Molecular Biology

Identification of ACSL4 as a biomarker and contributor of ferroptosis

Hua Yuan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Integrative & Complementary Medicine

Effects of Senegenin against hypoxia/reoxygenation-induced injury in PC12 cells

Zhu Xiao-qing et al.

CHINESE JOURNAL OF INTEGRATIVE MEDICINE (2016)

Review Medicine, General & Internal

Alzheimer's disease

Philip Scheltens et al.

LANCET (2016)

Review Medicine, General & Internal

The Role of Amyloid-β Oligomers in Toxicity, Propagation, and Immunotherapy

Urmi Sengupta et al.

EBIOMEDICINE (2016)

Article Geriatrics & Gerontology

Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids

Antonio Currais et al.

NPJ AGING AND MECHANISMS OF DISEASE (2016)

Review Nutrition & Dietetics

Acyl-CoA Metabolism and Partitioning

Trisha J. Grevengoed et al.

ANNUAL REVIEW OF NUTRITION, VOL 34 (2014)

Review Cell Biology

Lipid Peroxidation: Production, Metabolism, and Signaling Mechanisms of Malondialdehyde and 4-Hydroxy-2-Nonenal

Antonio Ayala et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2014)

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Biochemistry & Molecular Biology

Delineating the Role of Glutathione Peroxidase 4 in Protecting Cells Against Lipid Hydroperoxide Damage and in Alzheimer's Disease

Min-Hyuk Yoo et al.

ANTIOXIDANTS & REDOX SIGNALING (2010)

Review Biochemistry & Molecular Biology

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

P. Hemachandra Reddy et al.

TRENDS IN MOLECULAR MEDICINE (2008)

Article Biochemistry & Molecular Biology

Iron: The redox-active center of oxidative stress in Alzheimer disease

Rudy J. Castellani et al.

NEUROCHEMICAL RESEARCH (2007)

Review Biochemistry & Molecular Biology

Neuronal life-and-death signaling, apoptosis, and neurodegenerative disorders

Mark P. Mattson

ANTIOXIDANTS & REDOX SIGNALING (2006)