Journal
MOLECULAR MEDICINE
Volume 28, Issue 1, Pages -Publisher
SPRINGER
DOI: 10.1186/s10020-022-00536-y
Keywords
Necrotizing enterocolitis; Stem cells; Infants
Funding
- National Natural Science Foundation of China [82171709, 81801500]
- 345 Talent Project of Shengjing Hospital [M0275, M0279]
- Key R&D Guidance Plan Projects in Liaoning Province [2020JH1/10300001]
Ask authors/readers for more resources
This review discusses the therapeutic mechanisms through which stem cells may function in the treatment of necrotizing enterocolitis (NEC). Animal studies have shown that stem cells have anti-inflammatory, anti-apoptotic, and intestinal barrier enhancing effects, which may be protective against NEC.
Necrotizing enterocolitis (NEC) is a devastating gastrointestinal disease that affects newborns, particularly preterm infants, and is associated with high morbidity and mortality. No effective therapeutic strategies to decrease the incidence and severity of NEC have been developed to date. Stem cell therapy has been explored and even applied in various diseases, including gastrointestinal disorders. Animal studies on stem cell therapy have made great progress, and the anti-inflammatory, anti-apoptotic, and intestinal barrier enhancing effects of stem cells may be protective against NEC clinically. In this review, we discuss the therapeutic mechanisms through which stem cells may function in the treatment of NEC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available