4.6 Article

Covalent JNK Inhibitor, JNK-IN-8, Suppresses Tumor Growth in Triple-Negative Breast Cancer by Activating TFEB- and TFE3-Mediated Lysosome Biogenesis and Autophagy

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

How Lysosomes Sense, Integrate, and Cope with Stress

Paul Saftig et al.

Summary: Lysosomes play a crucial role in cellular metabolism and stress responses through regulating gene expression in the nucleus, sensing and integrating signals, and restoring cellular homeostasis in response to environmental changes. They contain a variety of proteins involved in these processes and form signaling complexes to transmit information.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

Review Oncology

Multifaceted activities of transcription factor EB in cancer onset and progression

Elena Astanina et al.

Summary: TFEB is an emerging transcription factor in cancer biology, playing a crucial role in regulating tumor growth and development by controlling the autophagy-lysosomal pathway. Its dysregulation has been found to have a crucial pathogenic role in different tumors, promising potential new druggable vulnerabilities in cancer treatment.

MOLECULAR ONCOLOGY (2021)

Article Cell Biology

TFEB regulates pluripotency transcriptional network in mouse embryonic stem cells independent of autophagy-lysosomal biogenesis

Anderson Tan et al.

Summary: TFEB plays a crucial role in mESCs by regulating PTN to maintain pluripotency, with interactions involving Nanog and Sox2. While high levels of TFEB are expected to enhance autophagy-lysosomal activity, undifferentiated mESCs surprisingly display low basal levels.

CELL DEATH & DISEASE (2021)

Review Pharmacology & Pharmacy

Activation of PI3K/AKT/mTOR Pathway Causes Drug Resistance in Breast Cancer

Chao Dong et al.

Summary: Hyperactivation of the PI3K/AKT/mTOR pathway is associated with drug resistance and cancer progression in breast cancer patients. Current research is focusing on developing drugs targeting this pathway to overcome acquired resistance to standard therapies.

FRONTIERS IN PHARMACOLOGY (2021)

Review Cell Biology

MiT/TFE Family of Transcription Factors: An Evolutionary Perspective

Martina La Spina et al.

Summary: Response and adaptation to stress are crucial for survival, and regulation of the transcriptional machinery by the MiT/TFE family of transcription factors is an important aspect of this process. These proteins, conserved through evolution, play key roles in cellular functions in response to various stresses. Their tissue expression and activities are highly regulated by alternative splicing, promoter usage, and posttranslational modifications. The study of MiT/TFE proteins and their transcriptional regulatory mechanisms is important for potential therapeutic targets in human diseases like lysosomal storage disorders, neurodegeneration, and cancer.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Review Cell Biology

Lysosomal Biology and Function: Modern View of Cellular Debris Bin

Purvi C. Trivedi et al.

CELLS (2020)

Article Cell Biology

Nutrient regulation of mTORC1 at a glance

Kendall J. Condon et al.

JOURNAL OF CELL SCIENCE (2019)

Article Biochemistry & Molecular Biology

TFEB controls vascular development by regulating the proliferation of endothelial cells

Gabriella Doronzo et al.

EMBO JOURNAL (2019)

Review Biochemistry & Molecular Biology

VPS34 complexes from a structural perspective

Yohei Ohashi et al.

JOURNAL OF LIPID RESEARCH (2019)

Review Biochemistry & Molecular Biology

The complex relationship between TFEB transcription factor phosphorylation and subcellular localization

Rosa Puertollano et al.

EMBO JOURNAL (2018)

Article Multidisciplinary Sciences

MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB

Cynthia L. Hsu et al.

NATURE COMMUNICATIONS (2018)

Article Multidisciplinary Sciences

mTOR-dependent phosphorylation controls TFEB nuclear export

Gennaro Napolitano et al.

NATURE COMMUNICATIONS (2018)

Article Medicine, Research & Experimental

The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology

Akinori Kawakami et al.

LABORATORY INVESTIGATION (2017)

Article Biochemistry & Molecular Biology

STUB1 regulates TFEB-induced autophagy-lysosome pathway

Youbao Sha et al.

EMBO JOURNAL (2017)

Article Multidisciplinary Sciences

METABOLISM Sestrin2 is a leucine sensor for the mTORC1 pathway

Rachel L. Wolfson et al.

SCIENCE (2016)

Review Oncology

Molecular Classification of Triple-Negative Breast Cancer

Sung Gwe Ahn et al.

JOURNAL OF BREAST CANCER (2016)

Review Oncology

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

Giampaolo Bianchini et al.

NATURE REVIEWS CLINICAL ONCOLOGY (2016)

Article Biochemistry & Molecular Biology

A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

Baptiste Ronan et al.

NATURE CHEMICAL BIOLOGY (2014)

Article Biochemical Research Methods

GSVA: gene set variation analysis for microarray and RNA-Seq data

Sonja Haenzelmann et al.

BMC BIOINFORMATICS (2013)

Article Cell Biology

Rag GTPases mediate amino acid-dependent recruitment of TFEB and MITF to lysosomes

Jose A. Martina et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Multidisciplinary Sciences

Klf4 Is a Transcriptional Regulator of Genes Critical for EMT, Including Jnk1 (Mapk8)

Neha Tiwari et al.

PLOS ONE (2013)

Article Chemistry, Medicinal

Discovery of CC-930, an orally active anti-fibrotic JNK inhibitor

Veronique Plantevin Krenitsky et al.

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2012)

Article Biochemistry & Molecular Biology

Discovery of Potent and Selective Covalent Inhibitors of JNK

Tinghu Zhang et al.

CHEMISTRY & BIOLOGY (2012)

Article Multidisciplinary Sciences

The clonal and mutational evolution spectrum of primary triple-negative breast cancers

Sohrab P. Shah et al.

NATURE (2012)

Article Biochemistry & Molecular Biology

Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation

Davis J. McCarthy et al.

NUCLEIC ACIDS RESEARCH (2012)

Article Biochemistry & Molecular Biology

Characterization of the CLEAR network reveals an integrated control of cellular clearance pathways

Michela Palmieri et al.

HUMAN MOLECULAR GENETICS (2011)

Article Endocrinology & Metabolism

JNK3 is abundant in insulin-secreting cells and protects against cytokine-induced apoptosis

S. Abdelli et al.

DIABETOLOGIA (2009)

Article Multidisciplinary Sciences

A Gene Network Regulating Lysosomal Biogenesis and Function

Marco Sardiello et al.

SCIENCE (2009)

Review Biochemistry & Molecular Biology

The c-jun kinase/stress-activated pathway: Regulation, function and role in human disease

Gary L. Johnson et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2007)

Article Biochemistry & Molecular Biology

Sumoylation of MITF and its related family members TFE3 and TFEB

AJ Miller et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)