Journal
MICROCHEMICAL JOURNAL
Volume 181, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.microc.2022.107715
Keywords
Metal-organic framework; Metal nanoparticles; Hydrogen peroxide; Electrochemical sensor; Living cells
Categories
Funding
- National Natural Science Foundation of China [82003710]
- Natural Science Foundation of Guangdong Province [2020A1515010075]
- Project of Educational Commission of Guangdong Province [2021ZDZX2012]
- National Key Clinical Specialty Construction Project (Clinical Pharmacy)
- High-Level Clinical Key Specialty (Clinical Pharmacy) in Guangdong Province
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In this study, metal-organic frameworks (MOFs) were used as supporting materials to enhance the electrocatalytic performance of metal nanoparticles. A self-supporting electrochemical sensor was developed by electrodeposition of metal nanoparticles on zinc-based MOFs. The results showed that silver nanoparticles modified two-dimensional MOFs exhibited better electrocatalytic activity, providing a promising platform for detecting biomarkers and drug evaluation.
Metal-organic frameworks (MOFs) can be used as Supporting Materials to support metal nanoparticles for enhanced electrocatalytic performance. In this work, electrodeposition of metal nanoparticles (NPs) on the zinc-based metal-organic frameworks (Zn-MOFs) with two types of morphologies was fabricated to develop a self-supporting electrochemical sensor. First, among the common metal nanoparticles, AgNPs has the best electrocatalytic activity than PtNPs and AuNPs towards H2O2 reduction. Secondly, the influences of different dimensions on the electrocatalytic activity of Zn-MOFs as Supporting Material were investigated. AgNPs modified two-dimensional Zn-MOFs (Ag/2D Zn-MOFs) exhibited better electrocatalytic activity than the AgNPs modified three-dimensional Zn-MOFs (Ag/3D Zn-MOFs). 2D MOFs can improve the dispersion and stability of the active metal components, provide a large specific surface area, and enhance high electrical conductivity. Under the optimal conditions, the Ag/2D Zn-MOFs modified electrodes displayed a low detection limit of 1.67 mu M (S/N = 3) with a wide linear range from 5.0 mu M to 70 mM. In addition, the modified electrode was evaluated for the real-time detection of H2O2 from living (normal and tumor) cells in response to the specifically drug-stimulated process. This metal nanoparticle/MOF nanozymes-based sensor can be used as an ideal platform for detecting biomarkers and drug evaluation.
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