Journal
MICROBIAL CELL FACTORIES
Volume 21, Issue 1, Pages -Publisher
BMC
DOI: 10.1186/s12934-022-01901-6
Keywords
Skin; Microbiota; Commensal microbes; Synthetic biology; Omics technologies; Host-skin microbiota interaction; Cutaneous diseases; Acne
Categories
Funding
- National Natural Science Foundation of China [32111530179]
- Novo Nordisk Foundation [NNF10CC1016517]
- Clinical Laboratories, Shenyou Bio
Ask authors/readers for more resources
This review provides insights into the interaction between human skin microbiota and human skin, the potential roles of microbiota in skin health and diseases, and the strategies for prevention, diagnosis, and treatment of microbe-related skin diseases.
Skin is the largest organ in the human body, and the interplay between the environment factors and human skin leads to some skin diseases, such as acne, psoriasis, and atopic dermatitis. As the first line of human immune defense, skin plays significant roles in human health via preventing the invasion of pathogens that is heavily influenced by the skin microbiota. Despite being a challenging niche for microbes, human skin is colonized by diverse commensal microorganisms that shape the skin environment. The skin microbiota can affect human health, and its imbalance and dysbiosis contribute to the skin diseases. This review focuses on the advances in our understanding of skin microbiota and its interaction with human skin. Moreover, the potential roles of microbiota in skin health and diseases are described, and some key species are highlighted. The prevention, diagnosis and treatment strategies for microbe-related skin diseases, such as healthy diets, lifestyles, probiotics and prebiotics, are discussed. Strategies for modulation of skin microbiota using synthetic biology are discussed as an interesting venue for optimization of the skin-microbiota interactions. In summary, this review provides insights into human skin microbiota recovery, the interactions between human skin microbiota and diseases, and the strategies for engineering/rebuilding human skin microbiota.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available