Journal
METABOLISM-CLINICAL AND EXPERIMENTAL
Volume 134, Issue -, Pages -Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.metabol.2022.155250
Keywords
Proteome modulation; Molecular pathways; Cardiotoxicity; Anticancer agents; Chemotherapy
Categories
Funding
- FCT-Fundacao para a Ciencia e a Tecnologia [UIDP/04378/2020, UIDB/04378/2020, LA/P/0140/2020]
- Associate Laboratory Institute for Health and Bioeconomy-i4HB
- European Social Fund (FSE) [SFRH/BD/138202/2018]
- FCT
- FCT, IP [SFRH/BHD/110001/2015, DL57/2016/CP1334/CT0006]
Ask authors/readers for more resources
This systematic review aims to provide an integrative perspective of the molecular mechanisms underlying the toxicity of anticancer agents on heart muscle using mass spectrometry (MS)-based proteomics. The results show that different anticancer agents have different mechanisms of cardiac toxicity, but the specific modulation is not completely elucidated.
Several anticancer agents have been associated with cardiac toxic effects. The currently proposed mechanisms to explain cardiotoxicity differ among anticancer agents, but in fact, the specific modulation is not completely elucidated. Thus, this systematic review aims to provide an integrative perspective of the molecular mechanisms underlying the toxicity of anticancer agents on heart muscle while using a high-throughput technology, mass spectrometry (MS)-based proteomics. A literature search using PubMed database led to the selection of 27 studies, of which 13 reported results exclusively on animal models, 13 on cardiomyocyte-derived cell lines and only one included both animal and a cardiomyocyte line. The reported anticancer agents were the proteasome
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
