Journal
METABOLIC BRAIN DISEASE
Volume 37, Issue 8, Pages 2711-2718Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11011-022-01071-9
Keywords
Anxiety; Obsessive-compulsive disorder; Cannabidiol; Obesity; High-carbohydrate diet
Categories
Funding
- Fundacao de Amparo Pesquisa Estado de Sao Paulo FAPESP [2017/24304-0]
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brasil (CAPES) [001]
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This study investigated the effects of cannabidiol (CBD) treatment on behavior problems induced by a high-refined carbohydrate diet. The results demonstrated that sub-chronic treatment with CBD could alleviate the compulsive-like and anxiogenic-like behavior caused by long-term consumption of a high-refined carbohydrate diet.
The excessive consumption of ultra-processed foods and the development of obesity has been associated with several comorbidities, including psychiatric disorders. Excess fat tissue promotes a low-intensity inflammatory state, mainly in the white tissue, which is essential in developing metabolic alterations and influences brain homeostasis. In this scenario, Cannabidiol (CBD), a compound from Cannabis sativa, has presented anxiolytic and anti-inflammatory effects in murine models. This study verified whether CBD treatment would ameliorate the compulsive-like and anxiety-like behaviors observed after mice's chronic consumption of a high-refined carbohydrate (HC) diet. BALB/c male mice received a control or HC diet for 12 weeks followed by vehicle and CBD (30 mg/Kg, i.p.) administration, and their behavior was evaluated in the Marble Burying test (MB) and Novel Suppressing Feeding test (NSF). The sub-chronic, but not acute, treatment with CBD attenuated the compulsive-like and anxiogenic-like behavior induced by the HC diet. Our data reinforced the harmful effects of the HC diet's chronic consumption on compulsive and anxious behaviors and the potential of CBD as a drug treatment for psychiatric disorders associated with obesity.
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