Journal
CARBOHYDRATE POLYMERS
Volume 116, Issue -, Pages 229-236Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2014.07.043
Keywords
Curcumin; Polysaccharide hydrogel; Galactomannan; Microemulsion; In-vitro skin permeation; Xanthan
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Funding
- National Research Council of Brazil (CNPq) [476950/2013-9]
- Araucaria Foundation (PRONEX-Carboidratos) [117/2010]
- Nanoglicobiotec-Ministry of Science and Technology/CNPq [564741/2010-8]
- Federal University of Parana-Brazil
- CNPq [306949/2012-1]
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The curcumin (CUR)-loaded binary hydrogel was formulated using xanthan and galactomannan from Schizolobium parahybae (guapuruvu). The binary hydrogels presented gel characteristics, stable pH values and mechanical stress resistance even after 45 days of heat exposure (45 degrees C). The CUR-loaded hydrogel content was 98.6% for XGMC (xanthan and galactomannan with CUR-microemulsion) after the stability test. The in vitro cytotoxicity analysis suggested non-cutaneous membrane irritation, and the in vitro skin permeation analysis indicated 2.15 to 2.50 mu g mL(-1) CUR at the stratum corneum, epidermal and dermal levels. The XGEC (xanthan and galactomannan with CUR solubilized in ethanol) and XGMC hydrogels presented 76.8 and 63.2% inhibition of topical inflammation, respectively. Chemical stability and non-cytotoxicity analysis confirm the safety of prolonged exposure of the skin during the topical treatment, offering long-lasting XGEC and XGMC action. (C) 2014 Elsevier Ltd. All rights reserved.
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