Formulation and process optimization of naproxen nanosuspensions stabilized by hydroxy propyl methyl cellulose

In present study precipitation-ultrasonication was used to obtain nanosuspensions of poorly water-soluble drug, naproxen (NPX). We investigated the effects of HPMC concentration (X-1) and time of ultrasonication (X-2) on imperative attributes like mean particle size (Y-1), % drug content (Y-2), and time required to 90% drug release (Y-3) via 3(2) factorial design. The morphology of nanosuspensions was found almost spherical by SEM observation. DSC and XRD studies suggested slight crystalline change in drug. FT-IR revealed lack of significant interactions between NPX and HPMC. Nanosuspensions of mean particle size 530.55 nm was achieved. Dissolution rate obtained from all nanosuspensions were markedly higher than pure NPX. Response surface methodology and optimized polynomial equations were used to select optimal formulation i.e. 1.36%W/V of X-1 and 13.9 min of X-2 to get desired response Y-1; 727.97 nm, Y-2; 95.59% and Y-3; 8.67 mm that were in reasonable agreement with observed value. (C) 2015 Elsevier Ltd. All rights reserved.