Journal
MEDICAL HYPOTHESES
Volume 166, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.mehy.2022.110926
Keywords
HIV; Covid-19; ACE2; S protein; Calanolides A; Holy Basil; Kuwanon-L; Patentiflorin A
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People living with HIV are at higher risk of adverse health effects during the COVID-19 pandemic. The pandemic has caused disruption in healthcare for those with HIV, leading to challenges in achieving optimal care outcomes.
People living with HIV are more exposed to the adverse health effects of the worldwide COVID-19 pandemic. The pandemic???s health and social repercussions may promote drug abuse and inadequate HIV management among this demographic. The coronavirus pandemic of 2019 (COVID-19) has caused unprecedented disruption worldwide in people???s lives and health care. When the COVID-19 epidemic was identified, people with HIV faced significant obstacles and hurdles to achieving optimal care results. The viral spike protein (S-Protein) and the cognate host cell receptor angiotensin-converting enzyme 2 (ACE2) are both realistic and appropriate inter-vention targets. Calanolides A, Holy Basil, Kuwanon-L, and Patentiflorin have anti-HIV effects. Our computa-tional biology study investigated that these compounds all had interaction binding scores related to S protein of coronavirus of-9.0 kcal /mol,-7.1 kcal /mol,-9.1 kcal /mol, and-10.3 kcal/mol/mol, respectively. A combination of plant-derived anti-HIV compounds like protease inhibitors and nucleoside analogs, which are commonly used to treat HIV infection, might be explored in clinical trials for the treatment of COVID-19.
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