Journal
MEDICAL CLINICS OF NORTH AMERICA
Volume 106, Issue 5, Pages 837-852Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.mcna.2022.03.002
Keywords
Overweight; Obesity; Medication; Pharmacotherapy; Medical devices; Endoscopic therapies; Bariatric surgery
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Obesity is a metabolic dysfunction disease with various contributing factors. The complex interplay between adipose tissue, muscle, the gut, and brain is being further understood, leading to the development of more effective and personalized therapies. While it is currently challenging to determine the most beneficial treatment for individual patients, a combination of lifestyle intervention with effective medications, devices, and bariatric surgery options can assist in achieving and maintaining weight loss.
Obesity is a disease characterized by metabolic dysfunction, with a variety of contrib-uting factors. These include genetic, epigenetic, social, environmental, and behavioral factors and a complex interplay between adipose tissue, muscle, the gut, and brain, and these connections continue to be elucidated. Our increased understanding of these connections will assist us with the creation of more effective and individualized therapies over time. Although it is currently not possible to determine which therapy will most benefit any individual patient, there are effective medications, devices, and bariatric surgery options, which are able to assist patients in achieving and sustaining weight loss when combined with lifestyle intervention.
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