Journal
JOURNAL OF INVESTIGATIVE SURGERY
Volume 29, Issue 4, Pages 226-233Publisher
TAYLOR & FRANCIS INC
DOI: 10.3109/08941939.2015.1105327
Keywords
pancreaticoduodenectomy; pancreatic duct drainage; pancreatic fistula; pancreas; pancreatic surgery; early efficacy
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Funding
- National Nature Scientific Foundation of China [81100314, 81170431, 81370565, 81372613]
- Research Special Fund For public welfare industry of health [201202007]
- New Century Support Foundation for Elitist of Heilongjiang Province in China [1253-NCET-017]
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Purpose: To compare the early efficacy of external versus internal pancreatic duct drainage after pancreaticoduodenectomy (PD), providing clinical evidence for selecting the optimal approach to pancreatic duct drainage. Material and Methods: The clinical data of 395 consecutive patients undergoing PD from 2006 to 2013 were analyzed retrospectively. All the patients were divided into external and internal drainage group. Intraoperative blood loss, surgery duration, postoperative hospitalization duration, mortality rate, PF, and other complications were compared between the two groups. The perioperative relative risk factors that might induce PF were analyzed. Results: External drainage significantly reduced the incidences of post-PD PF, delayed gastric emptying, abdominal infection, bowel obstruction, overall complications, and shortened the healing time of PF (p < .05). The univariate analysis showed that the pancreatic duct drainage method, body mass index (BMI), preoperative serum bilirubin level, perioperative blood transfusion, pancreaticojejunostomy approach, pancreatic texture, pancreatic duct diameter, and primary disease differed markedly between the two groups (p < .05). A multivariate analysis revealed that BMI 25kg/m(2), internal pancreatic duct drainage, pancreatic duct diameter <3mm, soft pancreatic texture, and ampullary disease were independent risk factors for PF. Conclusions: External pancreatic duct drainage can effectively reduce the morbidity of PF and overall complications after PD.
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