Journal
JOURNAL OF INVESTIGATIVE MEDICINE
Volume 64, Issue 6, Pages 1078-1081Publisher
BMJ PUBLISHING GROUP
DOI: 10.1136/jim-2016-000204
Keywords
Liver Diseases; Alcoholic; Fatty Liver
Funding
- National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health
- VA Merit Award [1I01CX000361]
- NIH [U01AA021840]
- US DOD [W81XWH-12-1-0497]
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Alcoholic liver disease (ALD) is a major public health problem worldwide and is the leading cause of end-stage liver disease. While the ultimate control of ALD will require the prevention of alcohol abuse, better understanding of the mechanisms of alcohol-induced liver injury may lead to treatments of fatty liver, alcoholic hepatitis, and prevention or delay of occurrence of cirrhosis. The elucidation and the discovery of several new concepts in ALD pathogenesis have raised our understanding on the complex mechanisms and the potential in developing the new strategies for therapeutic benefits. In this review, we provide the most up-to-date information on the basic molecular mechanisms focusing on the role of fat-specific protein 27/CIDEC in the pathogenesis of ALD.
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