An antibacterial coaxial electrospun polylactic acid/silk fibroin loaded with nano-ZnO and Voltaren

The coaxial electrospinning was used to prepare Voltaren-loaded and nano-ZnO-loaded core-shell polylactic acid (PLA)/silk fibroin (SF) fibers. The elemental morphology, compositions, the release behavior and the antibacterial property of the fibers were investigated. The result showed that the fibers had a clear core-shell structure and nano-ZnO was observed in the shell. The cumulative drug release rates of core-shell fibers were 48.8% and 72.6% at 100 min and 600 min, respectively. The core-shell PLA/SF had a smaller initial release of Voltaren and an obvious antibacterial activity against Escherichia coli and Staphylococcus aureus under an absence of light.

Automated summary

The coaxial electrospinning method was used to fabricate core-shell fibers loaded with drugs and nano-materials. The results showed that the fibers exhibited a distinct core-shell structure and demonstrated antibacterial activity.