Journal
JOURNAL OF INVESTIGATIVE DERMATOLOGY
Volume 136, Issue 11, Pages 2133-2139Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jid.2016.06.621
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Funding
- NIAMS NIH HHS [K08 AR070289, T32 AR007465] Funding Source: Medline
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Cellular senescence, a state of stable cell cycle arrest in response to cellular stress, is an indispensable mechanism to counter tumorigenesis by halting the proliferation of damaged cells. However, through the secretion of an array of diverse cytokines, chemokines, growth factors, and proteases known as the senescence-associated secretory phenotype (SASP), senescent cells can paradoxically promote carcinogenesis. Consistent with this, removal of senescent cells delays the onset of cancer and prolongs lifespan in vivo, potentially in part through SASP reduction. In this review, we consider the evidence for the SASP and SASP-like inflammation in driving skin carcinogenesis, emphasizing how further understanding of both the roles and mechanisms of SASP expression may offer new targets for skin cancer prevention and therapy.
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