Aromatic Polyketides from the Deep-Sea Cold-Seep Mussel Associated Endozoic Fungus Talaromyces minioluteus CS-138

Article Chemistry, Medicinal

Six New Antimicrobial Metabolites from the Deep-Sea Sediment-Derived Fungus Aspergillus fumigatus SD-406

Li-Hong Yan et al.

Summary: Six new metabolites and six known compounds were isolated and identified from a deep-sea sediment-derived fungus. The new metabolites showed inhibitory activities against bacteria and fungi.

MARINE DRUGS (2022)

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Article Chemistry, Organic

Chevalinulins A and B, Proangiogenic Alkaloids with a Spiro[bicyclo[2.2.2]octane-diketopiperazine] Skeleton from Deep-Sea Cold-Seep-Derived Fungus Aspergillus chevalieri CS-122

Li-Hong Yan et al.

Summary: In this study, two indolediketopiperazine alkaloids containing an unprecedented spiro-[bicyclo[2.2.2]octane-diketopiperazine] skeleton were isolated from a deep-sea cold-seep-derived fungus. The structures of these compounds were determined through various methods. Both compounds exhibited significant in vivo proangiogenic activity in transgenic zebrafish.

ORGANIC LETTERS (2022)

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Article Plant Sciences

Cytochalasin Derivatives from the Endozoic Curvularia verruculosa CS-129, a Fungus Isolated from the Deep-Sea Squat Lobster Shinkaia crosnieri Living in the Cold Seep Environment

Xue-Yi Hu et al.

Summary: New cytochalasin compounds were isolated from an endozoic fungus obtained from the deep-sea squat lobster in the cold seep area of the South China Sea. These compounds included a novel cytochalasin homodimer containing a thioether bridge and the first 12-nor-cytochalasin derivative. Some of these compounds exhibited activity against human pathogenic bacteria and cytotoxicity against tumor cell lines.

JOURNAL OF NATURAL PRODUCTS (2021)

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Editorial Material Chemistry, Medicinal