Journal
MARINE DRUGS
Volume 20, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/md20110667
Keywords
Aphrocallistes vastus lectin; oncolytic vaccinia virus; AP-1; hepatocellular carcinoma
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Funding
- National Natural Science Foundation of China [81972281]
- Natural Science Foundation of Zhejiang Province [LGF22C010005]
- Hangzhou Gongchu Biotechnology Co., Ltd.
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This study reveals that AVL lectin can increase levels of inflammatory cytokines in hepatocellular carcinoma cells through activating the AP-1 signaling pathway, offering new insights into cancer therapy.
Aphrocallistes vastus lectin (AVL) is a C-type marine lectin derived from sponges. Our previous study demonstrated that oncolytic vaccinia virus carrying AVL (oncoVV-AVL) significantly enhanced the cytotoxicity of oncoVV in cervical cancer, colorectal cancer and hepatocellular carcinoma through the activation of Ras/ERK, MAPK/ERK and PI3K/Akt signaling pathways. In this study, the inflammatory response induced by oncoVV-AVL in a hepatocellular carcinoma cell (HCC) model was investigated. The results showed that oncoVV-AVL increased the levels of inflammatory cytokines including IL-6, IL-8 and TNF-alpha through activating the AP-1 signaling pathway in HCC. This study provides novel insights into the utilization of lectin AVL in the field of cancer therapy.
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