4.5 Article

Preparation of a novel group of chemiluminescent N-substituted acridinium esters

Journal

LUMINESCENCE
Volume 37, Issue 11, Pages 1982-1990

Publisher

WILEY
DOI: 10.1002/bio.4385

Keywords

acridinium ester; chemiluminescence immunoassay; quantum yield; synthesis

Funding

  1. Molecular Light Technology Research Limited
  2. Cardiff University
  3. Chinese Government
  4. King Saud University
  5. UK Government

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Several novel N-substituted acridinium esters have been synthesized and their chemiluminescent properties have been tested. The characteristics of the substituent on the nitrogen atom were found to affect their chemiluminescent efficiency and hydrolytic stability. Additionally, dibromo-substituted leaving groups slightly accelerated the chemiluminescence process.
Several novel N-substituted acridinium esters 7-16 containing a 10-methyl, 10-dodecyl, or 10-(omega-[succinimidyloxycarbonyl]alkyl) group have been synthesized and their chemiluminescent properties have been tested. Their chemiluminescent efficiencies and hydrolytic stabilities have been found to be affected by the characteristics of the group on the nitrogen atom. Dibromo-substituted leaving groups slightly accelerate the chemiluminescence process.

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