☆ 4.5 Article

Intervention time decides the status of autophagy, NLRP3 activity and apoptosis in macrophages induced by ox-LDL

LIPIDS IN HEALTH AND DISEASE (2022)

Related references

Note: Only part of the references are listed.

Article Pharmacology & Pharmacy

Calycosin ameliorates atherosclerosis by enhancing autophagy via regulating the interaction between KLF2 and MLKL in apolipoprotein E gene-deleted mice

Chuanrui Ma et al.

Summary: This study showed that calycosin protects against atherosclerosis through promoting autophagy, inhibiting foam cell formation, inflammation, and apoptosis. It also identified MLKL as a new autophagy regulator that is negatively regulated by KLF2. Mechanistically, calycosin's inhibitory effects on atherogenesis are mediated through the KLF2-MLKL signaling pathway modulation.

BRITISH JOURNAL OF PHARMACOLOGY (2022)

Add to Collection

Review Endocrinology & Metabolism

A Modern Approach to Dyslipidemia

Amanda J. Berberich et al.

Summary: Lipid disorders are common in clinical practice and have implications for cardiovascular risk and overall health. Recent advances have led to updated approaches, including new classification schemes and diagnostic methods based on routine lipid panels. The development of new drugs provides additional management options for lipid disorders.

ENDOCRINE REVIEWS (2022)

Add to Collection

Article Multidisciplinary Sciences

Wetting regulates autophagy of phase-separated compartments and the cytosol

Jaime Agudo-Canalejo et al.

Summary: This study explores how autophagosomes sequester droplets containing p62 protein in cells and demonstrates the formation of double-membrane, autophagosome-like vesicles on protein-free droplets through partial wetting in vitro. A minimal physical model shows that droplet surface tension supports the formation of membrane sheets. The interaction between the material properties of droplets and membrane sheets elucidates the mechanisms underlying droplet autophagy.

NATURE (2021)

Add to Collection

Article Cell Biology

MicroRNA-130a inhibits proliferation of vascular smooth muscle cells by suppressing autophagy via ATG2B

Liang Zheng et al.

Summary: The research identified miR-130a as a significantly down-regulated microRNA in arteriosclerosis obliterans, with a function in regulating cell proliferation by controlling autophagy. MiR-130a inhibits VSMCs proliferation by suppressing autophagy, suggesting it as a potential therapeutic target in regulating autophagy in atherosclerosis obliterans.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Add to Collection

Editorial Material Cardiac & Cardiovascular Systems

The year 2020 in Atherosclerosis

Christoph J. Binder et al.

ATHEROSCLEROSIS (2021)

Add to Collection

Letter Cardiac & Cardiovascular Systems

Early-Life Initiation of Primary Prevention Strategies to Reduce Atherosclerosis Risk

Gloria Aguilo et al.

JAMA CARDIOLOGY (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Novel Therapeutical Approaches to Managing Atherosclerotic Risk

Rosaria Vincenza Giglio et al.

Summary: Atherosclerosis is a multifactorial vascular disease characterized by inflammation and stiffening of arteries. Therapeutic strategies such as PCSK9 inhibitors, inclisiran, bempedoic acid, GLP-1 RAs, and nutraceuticals show promise in improving atheromatous plaque through actions on LDL-Receptor, endothelial dysfunction, macrophage activation, lipid oxidation, foam cell formation, and extracellular lipid deposition. The reduction of atheroma plaque by intensive LDL-Cholesterol lowering and addressing inflammation and other risk factors is crucial in managing atherosclerotic disease.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Review Biotechnology & Applied Microbiology

Targeting inflammation in atherosclerosis - from experimental insights to the clinic

Oliver Soehnlein et al.

Summary: Inflammation plays a substantial role in atherosclerosis and targeting inflammatory pathways could provide a promising new avenue to prevent and treat the disease. Clinical studies have shown that modulation of inflammation can help prevent the clinical complications of atherosclerosis. Refining strategies for combatting inflammation in the disease is crucial for further progress in managing atherosclerotic risk.

NATURE REVIEWS DRUG DISCOVERY (2021)

Add to Collection

Review Cardiac & Cardiovascular Systems

New and emerging lipid-lowering therapy

James M. Backes et al.

Summary: Statins are the preferred medications for patients at risk of or with atherosclerotic cardiovascular disease, although new investigational agents are being developed to manage dyslipidemias and lower ASCVD risk. Many of these new drugs, known as biologics, have complex mechanisms of action and must be given as injections, making them expensive but potentially effective for patients unable to take statins or with rare cholesterol disorders.

FUTURE CARDIOLOGY (2021)

Add to Collection

Review Cardiac & Cardiovascular Systems

Familial Hypercholesterolemia: Global Burden and Approaches

Lale Tokgozoglu et al.

Summary: Familial hypercholesterolemia (FH) is a common genetic disorder characterized by markedly elevated LDL-C levels from birth onward, resulting in significantly increased risk for ASCVD. Despite major advances in our understanding of the disease and effective therapies, FH is still underdiagnosed and undertreated. Early initiation of LDL-C lowering by increased awareness of FH among healthcare professionals, patients, and the public is necessary to achieve meaningful reduction in ASCVD morbidity and mortality in these patients.

CURRENT CARDIOLOGY REPORTS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Treatment of Dyslipidaemia in Children

Riccardo Fiorentino et al.

Summary: Childhood dyslipidaemia is a major risk factor for cardiovascular disease, and the first-line treatment involves healthy lifestyle changes such as diet modifications and exercise. Parents play a crucial role in promoting healthy habits for their children, and pharmacological therapy is an option for those with severe lipid abnormalities not improved by healthy behaviors. Further studies are needed to assess the long-term efficacy and safety of novel lipid-lowering drugs in children.

BIOMEDICINES (2021)

Add to Collection

Review Cardiac & Cardiovascular Systems

Dyslipidemia in pediatrician's practice

Alla Burlutskaya et al.

Summary: Atherosclerosis is a leading disease in the cardiovascular system, with over 50% of people with circulatory pathology dying from it. Dyslipidemias are highly prevalent in children, highlighting the importance of timely diagnostic and preventive measures.

REVIEWS IN CARDIOVASCULAR MEDICINE (2021)

Add to Collection

Article Cardiac & Cardiovascular Systems

The burden of cholesterol accumulation through the lifespan: why pharmacological intervention should start earlier to go further?

Alberto Zambon et al.

Summary: Atherosclerosis is closely related to atherogenic lipoproteins, and lifelong elevations in these lipoproteins increase the risk of future atherosclerosis. Adolescence and early adulthood are critical periods for determining future cardiovascular disease risk.

EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY (2021)

Add to Collection

Review Hematology

Evidence-Based Medical Management of Peripheral Artery Disease

Graham H. Bevan et al.

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Aldehyde dehydrogenase 2 inhibited oxidized LDL-induced NLRP3 inflammasome priming and activation via attenuating oxidative stress

Youshun Xu et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Add to Collection

Review Medicine, Research & Experimental

Targeting foam cell formation and macrophage polarization in atherosclerosis: The Therapeutic potential of rhubarb

Xianfeng Liu et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

Add to Collection

Review Cell Biology

Mechanistic Insights into the Oxidized Low-Density Lipoprotein-Induced Atherosclerosis

Chainika Khatana et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

Add to Collection

Review Immunology

Interplay Between NLRP3 Inflammasome and Autophagy

Monika Biasizzo et al.

FRONTIERS IN IMMUNOLOGY (2020)

Add to Collection

Article Cell Biology

Oxidized LDL Disrupts Metabolism and Inhibits Macrophage Survival by Activating a miR-9/Drp1/Mitochondrial Fission Signaling Pathway

Ting Xin et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

Add to Collection

Article Cardiac & Cardiovascular Systems

Cardiovascular Risk Reduction in High-Risk Pediatric Patients A Scientific Statement From the American Heart Association

Sarah D. de Ferranti et al.

CIRCULATION (2019)

Add to Collection

Article Cardiac & Cardiovascular Systems

Anticytokine Agents Targeting Interleukin Signaling Pathways for the Treatment of Atherothrombosis

Paul M. Ridker

CIRCULATION RESEARCH (2019)

Add to Collection

Review Immunology

NLRP3 inflammasome as a treatment target in atherosclerosis: A focus on statin therapy

Negin Parsamanesh et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

Add to Collection

Article Medicine, Research & Experimental

Knockdown of LSD1 meliorates Ox-LDL-stimulated NLRP3 activation and inflammation by promoting autophagy via SESN2-mesiated PI3K/Akt/mTOR signaling pathway

Xiaozhen Zhuo et al.

LIFE SCIENCES (2019)

Add to Collection

Article Cardiac & Cardiovascular Systems

Effect of statins on atherosclerotic plaque

Shone O. Almeida et al.

TRENDS IN CARDIOVASCULAR MEDICINE (2019)

Add to Collection

Review Cell Biology

NLRP3 inflammasome: Its regulation and involvement in atherosclerosis

Zahra Hoseini et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2018)

Add to Collection

Article Biochemistry & Molecular Biology

Recombinant Human Thioredoxin-1 Protects Macrophages from Oxidized Low-Density Lipoprotein-Induced Foam Cell Formation and Cell Apoptosis

Hui Zhang et al.

BIOMOLECULES & THERAPEUTICS (2018)

Add to Collection

Review Cardiac & Cardiovascular Systems

NLRP3 Inflammasome and the IL-1 Pathway in Atherosclerosis

Alena Grebe et al.

CIRCULATION RESEARCH (2018)

Add to Collection

Review Medicine, Research & Experimental

LOX-1 receptor: A potential link in atherosclerosis and cancer

Silvana Balzan et al.

LIFE SCIENCES (2018)

Add to Collection

Review Pharmacology & Pharmacy

Inflammation and beyond: new directions and emerging drugs for treating atherosclerosis

Marie-Jeanne Bertrand et al.

EXPERT OPINION ON EMERGING DRUGS (2017)

Add to Collection

Review Peripheral Vascular Disease

Role of NLRP3 Inflammasomes in Atherosclerosis

Tadayoshi Karasawa et al.

JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS (2017)

Add to Collection

Article Biochemistry & Molecular Biology

Inflammasome and Autophagy Regulation: A Two-way Street

Qian Sun et al.

MOLECULAR MEDICINE (2017)

Add to Collection

Article Multidisciplinary Sciences

Hypoxia ameliorates intestinal inflammation through NLRP3/mTOR downregulation and autophagy activation

Jesus Cosin-Roger et al.

NATURE COMMUNICATIONS (2017)

Add to Collection

Review Peripheral Vascular Disease

Oxidative Stress in Atherosclerosis

Ajoe John Kattoor et al.

CURRENT ATHEROSCLEROSIS REPORTS (2017)

Add to Collection

Review Cardiac & Cardiovascular Systems

Translational atherosclerosis research: From experimental models to coronary artery disease in humans

Christian A. Gleissner

ATHEROSCLEROSIS (2016)

Add to Collection

Review Immunology

Crosstalk between autophagy and inflammatory signalling pathways: balancing defence and homeostasis

Ken Cadwell

NATURE REVIEWS IMMUNOLOGY (2016)

Add to Collection

Article Cell Biology

Autophagy is associated with cell fate in the process of macrophage-derived foam cells formation and progress

Xiaopeng Liu et al.

JOURNAL OF BIOMEDICAL SCIENCE (2016)

Add to Collection

Review Cardiac & Cardiovascular Systems

Inflammation and Immunity in Diseases of the Arterial Tree Players and Layers

Peter Libby et al.

CIRCULATION RESEARCH (2015)

Add to Collection

Article Neurosciences

Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis

Xin Shi et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2015)

Add to Collection

Article Neurosciences

Expression of the NLRP3 Inflammasome in Carotid Atherosclerosis

Xin Shi et al.

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES (2015)

Add to Collection

Article Cell Biology

Silence of NLRP3 Suppresses Atherosclerosis and Stabilizes Plaques in Apolipoprotein E-Deficient Mice

Fei Zheng et al.

MEDIATORS OF INFLAMMATION (2014)

Add to Collection

Article Biochemistry & Molecular Biology

Oxidized low-density lipoprotein induces secretion of interleukin-1β by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation

Yugang Jiang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2012)

Add to Collection

Article Cell Biology

Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis

Xianghai Liao et al.

CELL METABOLISM (2012)

Add to Collection

Review Biochemistry & Molecular Biology

Atherosclerosis: current pathogenesis and therapeutic options

Christian Weber et al.

NATURE MEDICINE (2011)

Add to Collection

Article Multidisciplinary Sciences

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

Peter Duewell et al.

NATURE (2010)

Add to Collection

Review Chemistry, Medicinal

Apoptosis in atherosclerosis: A mini-review

Maria Karaflou et al.

MINI-REVIEWS IN MEDICINAL CHEMISTRY (2008)

Add to Collection

Review Multidisciplinary Sciences

Autophagy fights disease through cellular self-digestion

Noboru Mizushima et al.

NATURE (2008)

Add to Collection

Article Immunology

NALP3 forms an IL-lβ-Processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder

L Agostini et al.

IMMUNITY (2004)

Add to Collection

Review Biochemistry & Molecular Biology

Oxidized low-density lipoprotein-induced apoptosis

R Salvayre et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2002)

Add to Collection

© Peeref 2019-2024. All rights reserved.