Journal
LIFE SCIENCES
Volume 306, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.lfs.2022.120803
Keywords
Inflammatory bowel disease; Membrane vesicles; Microecology; Intestinal epithelial barrier; Microbiota
Funding
- Zhejiang Provincial Natural Science Foundation of China [LY22B070007]
- National Natural Science Foundation of China [21777146]
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Inflammatory bowel disease (IBD) is a chronic intestinal inflammation with no cure. Disruption of the microbial ecosystem in the intestine is considered a key factor in IBD. Bacterial membrane vesicles (MVs) play important roles in regulating intestinal microecology and have potential therapeutic applications in IBD patients.
Inflammatory bowel disease (IBD) is characterized by chronic intestinal inflammation with no cure. The intestine is fundamental in controlling human health. Disruption of the microbial ecosystem in the intestine is considered an important cause of IBD. The interaction between the host and microbiota significantly impacts the intestinal epithelial barrier and immune function. Bacterial membrane vesicles (MVs) are vital participants in bacteria-bacteria and host-microbiota communication. Currently, MVs have been found to exhibit many important regulating effects for intestinal microecology and have excellent application potential in clinical disease therapies. In the present review, we review the current knowledge on MVs, and specifically focus on gut bacterial MVs and their roles in the IBD. In addition, we summarized the potential utility of MVs as a novel therapeutic approach in IBD patients.
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