Environmental bacteria as triggers to brain disease: Possible mechanisms of toxicity and associated human risk

Aims: Brain disease, in its many forms, has recently demonstrated a great socio-economic impact and represents one of the hardest challenges of present research. Although each pathology of this highly heterogenous group is characterized by individual features, there is an increasing number of common toxicological mechanisms that have been evidenced. This review aims to summarize the state-of-art knowledge concerning the role of envi-ronmental bacteria in brain diseases focusing on different mechanisms of action that could be interacting in an additive or synergistic way.Materials and methods: For this wide-range subject, we focused on two emerging types of bacterial-derived brain exposure and damage and specifically treated representative examples: i) environmental bacterial-derived compounds in the form of the cyanobacterial product BMAA (beta-N-methylamino-L-alanine) toxin and its iso-mers DAB (2,4-diaminobutyric acid) and AEG (N-(2-aminoethyl)glycine) and ii) toxicity related to bacterial infections in the form of the emerging Lyme neuroborreliosis (LNB), determined by Borrelia burgdorferi (Bb). Key findings: Defined as pleiotropic contaminants, BMAA and Bb act through multiple toxicological pathways including inflammation, oxidative stress and excitotoxicity. Multiple investigations in in vitro and in vivo models have underlined the involved mechanisms of action but further investigations are needed to clarify the role of possible cocktail effects and underline possible new targets of intervention.Significance: Environmental bacteria represent emerging risk factors because of environmental changes, anthropogenic activities and human lifestyle evolutions. Future directions and research ambitions are here discussed in order to evaluate human risk and possible ways of intervention and prevention.

Automated summary

This review discusses the role of environmental bacteria in brain diseases, focusing on the impact of environmental bacterial compounds and toxicity related to bacterial infections. Findings reveal that environmental bacteria can cause brain damage through multiple toxicological pathways, emphasizing the need for further research to clarify cocktail effects and potential new intervention targets.