4.3 Letter

Transcriptional deregulation of LSD1 and LSD2 is associated with cytogenetic risk in chronic lymphocytic leukemia

Related references

Note: Only part of the references are listed.
Article Hematology

Cytogenetics in Chronic Lymphocytic Leukemia: ERIC Perspectives and Recommendations

Panagiotis Baliakas et al.

Summary: Cytogenetic analysis has increasing clinical value in CLL, particularly for identifying complex karyotype as a prognostic and predictive biomarker. However, explicit recommendations for CBA and CMA methodology and clinical interpretation are still lacking. ERIC presents consensus on CBA/CMA and encourages their wide application in clinical trials to improve risk stratification and management, although CMA data is limited.

HEMASPHERE (2022)

Article Cell Biology

Nucleolar and spindle associated protein 1 enhances chemoresistance through DNA damage repair pathway in chronic lymphocytic leukemia by binding with RAD51

Yang Han et al.

Summary: The study revealed that NUSAP1 is significantly overexpressed in CLL and modulating its levels can affect cell proliferation, apoptosis, and cell cycle arrest in CLL cells. Additionally, reducing NUSAP1 enhances sensitivity of CLL cells to chemotherapy, indicating its potential as a therapeutic target for CLL with chemotherapy resistance.

CELL DEATH & DISEASE (2021)

Review Biochemistry & Molecular Biology

Biological roles of LSD1 beyond its demethylase activity

Feiying Gu et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2020)

Review Oncology

LSD1/KDM1A inhibitors in clinical trials: advances and prospects

Yuan Fang et al.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2019)

Article Biochemistry & Molecular Biology

BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis

Frederik Otzen Bagger et al.

NUCLEIC ACIDS RESEARCH (2016)

Article Cell Biology

The histone demethylase LSD1/KDM1A promotes the DNA damage response

Nima Mosammaparast et al.

JOURNAL OF CELL BIOLOGY (2013)

Article Biochemical Research Methods

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Da Wei Huang et al.

NATURE PROTOCOLS (2009)

Article Multidisciplinary Sciences

p53 is regulated by the lysine demethylase LSD1

Jing Huang et al.

NATURE (2007)

Article Multidisciplinary Sciences

Dido disruption leads to centrosome amplification and mitotic checkpoint defects compromising chromosome stability

Varvara Trachana et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)