4.6 Article

Ultrasmall Pt Nanozymes Immobilized on Spherical Polyelectrolyte Brushes with Robust Peroxidase-like Activity for Highly Sensitive Detection of Cysteine

Journal

LANGMUIR
Volume 38, Issue 42, Pages 12915-12923

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.2c02056

Keywords

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Funding

  1. Key Scientific and Technological Project of Xinjiang Bingtuan
  2. National Natural Science Foundation of China
  3. [2018AB025]
  4. [51773061]
  5. [51761135128]

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SPB-stabilized ultrasmall Pt NPs exhibited outstanding peroxidase-like activity and were used to establish a colorimetric sensor for cysteine detection.
Distinct platinum (Pt) nanozymes as peroxidase mimics have received extensive interest owing to their outstanding catalytic activity, high environmental tolerance, lower consumption, and great potential in replacing natural enzymes. However, easy agglomeration of Pt nanoparticles (Pt NPs) resulting from the high surface free energy significantly decrease their peroxidase-like activity. Herein, spherical polyelectrolyte brush (SPB)-stabilized ultrasmall Pt NPs (SPB@Pt NPs) were prepared by a novel synthetic strategy where the SPB not only performed as a nanoreactor for the synthesis of ultrasmall Pt NPs but also greatly stabilized Pt NPs against aggregation. The well-defined SPB@Pt NP nanozymes exhibited outstanding peroxidase-like activity for the catalytic oxidation of colorless 3,3 ',5,5 '-tetramethylbenzidine (TMB) to blue oxidized TMB and were then used to establish a colorimetric sensor for rapid detection of cysteine, giving a limit of detection of 0.11 mu M. Moreover, the colorimetric detection system was demonstrated with outstanding performance in sensitive and selective detection of cysteine in the presence of several interference molecules. From these results, SPB@Pt NPs have been regarded as promising peroxidase mimics for a large number of applications such as in biosensing, biomedicine, the food industry, and environmental chemistry.

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