Journal
LANGMUIR
Volume -, Issue -, Pages -Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.langmuir.2c02086
Keywords
-
Funding
- University of Reading
- European Union [2020-MSCA-RISE-2018/823883]
- Leverhulme Trust [VP2-2020-013]
Ask authors/readers for more resources
Liposomes with different modifications were formulated and their physicochemical characteristics and retention on ex vivo eye tissues were evaluated. The maleimide-decorated liposomes showed the best retention performance on bovine conjunctiva compared to other liposomal formulations.
Liposomes are promising spherical vesicles for topical drug delivery to the eye. Several types of vesicles were formulated in this study, including conventional, PEGylated, and maleimide-decorated PEGylated liposomes. The physicochemical characteristics of these liposomes, including their size, zeta potential, ciprofloxacin encapsulation efficiency, loading capacity, and release, were evaluated. The structure of these liposomes was examined using dynamic light scattering, transmission electron microscopy, and small angle neutron scattering. The ex vivo corneal and conjunctival retention of these liposomes were examined using the fluorescence flow-through method. Maleimide-decorated liposomes exhibited the best retention performance on bovine conjunctiva compared to other types of liposomes studied. Poor retention of all liposomal formulations was observed on bovine cornea.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available