Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 25, Issue 29, Pages 4717-4729Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201501582
Keywords
core-shell nanoparticles; bioimaging; upconversion; drug loading; antitumor chemotherapy
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Funding
- National Natural Science Foundation of China (NSFC) [51332008, 51372243, 51422209, 51202239]
- National Basic Research Program of China [2014CB643803]
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In this work, a simple method is demonstrated for the synthesis of multifunctional core-shell nanoparticles NaYF4:Yb,Er@NaYF4:Yb@NaNdF4:Yb@NaYF4:Yb@PAA (labeled as Er@Y@Nd@Y@PAA or UCNP@PAA), which contain a highly effective 808-nm-to-visible UCNP core and a thin shell of poly(acrylic acid) (PAA) to achieve upconversion bioimaging and pH-sensitive anticancer chemotherapy simultaneously. The core-shell Nd3+-sensitized UCNPs are optimized by varying the shell number, core size, and host lattices. The final optimized Er@Y@Nd@Y nanoparticle composition shows a significantly improved upconversion luminescence intensity, that is, 12.8 times higher than Er@Y@Nd nanoparticles. After coating the nanocomposites with a thin layer of PAA, the resulting UCNP@PAA nanocomposite perform well as a pH-responsive nanocarrier and show clear advantages over UCNP@mSiO(2), which are evidenced by in vitro/in vivo experiments. Histological analysis also reveals that no pathological changes or inflammatory responses occur in the heart, lungs, kidneys, liver, and spleen. In summary, this study presents a major step forward towards a new therapeutic and diagnostic treatment of tumors by using 808-nm excited UCNPs to replace the traditional 980-nm excitation.
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