Effects of sleep deprivation on coronary heart disease

The presence of artificial light enables humans to be active 24 h a day. Many people across the globe live in a social culture that encourages staying up late to meet the demands of various activities, such as work and school. Sleep de -privation (SD) is a severe health problem in modern society. Meanwhile, as with cardiometabolic disease, there was an obvious tendency that coronary heart disease (CHD) to become a global epidemic chronic disease. Specifically, SD can significantly increase the morbidity and mortality of CHD. However, the underlying mechanisms responsible for the effects of SD on CHD are multilayered and complex. Inflammatory response, lipid metabolism, oxidative stress, and endothelial function all contribute to cardiovascular lesions. In this review, the effects of SD on CHD development are summarized, and SD-related pathogenesis of coronary artery lesions is discussed. In general, early assessment of SD played a vital role in preventing the harmful conse-quences of CHD.

Automated summary

The presence of artificial light allows humans to be active 24/7, but sleep deprivation is a serious health issue that can increase the risk of coronary heart disease. There are multiple mechanisms, including inflammatory response, lipid metabolism, oxidative stress, and endothelial function, that contribute to cardiovascular lesions. Therefore, early assessment of sleep deprivation is crucial in preventing the harmful consequences of coronary heart disease.