Journal
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
Volume 23, Issue 9, Pages 705-731Publisher
ZHEJIANG UNIV PRESS
DOI: 10.1631/jzus.B2200047
Keywords
Food allergy; Oral immunotherapy; Biomarker; Immune tolerance; Desensitization
Categories
Funding
- Talent Training Project of Northwest Women's and Children's Hospital [2018LQ01]
- National Natural Science Foundation of China [82070858]
- Natural Science Foundation of Shaanxi Province, China [2020JQ-941, 2021JQ-911]
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Food allergy is a global health problem, and effective treatment is needed. Oral immunotherapy has shown good efficacy and safety in most patients. Reliable biomarkers are needed for evaluating treatment effectiveness and predicting outcomes during oral immunotherapy.
Food allergy (FA) is a global health problem that affects a large population, and thus effective treatment is highly desirable. Oral immunotherapy (OIT) has been showing reasonable efficacy and favorable safety in most FA subjects. Dependable biomarkers are needed for treatment assessment and outcome prediction during OIT. Several immunological indicators have been used as biomarkers in OIT, such as skin prick tests, basophil and mast cell reactivity, T cell and B cell responses, allergen-specific antibody levels, and cytokines. Other novel indicators also could be potential biomarkers. In this review, we discuss and assess the application of various immunological indicators as biomarkers for OIT.
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