☆ 4.6 Article

Variations in Cell Surface ACE2 Levels Alter Direct Binding of SARS-CoV-2 Spike Protein and Viral Infectivity: Implications for Measuring Spike Protein Interactions with Animal ACE2 Orthologs

JOURNAL OF VIROLOGY (2022)

Related references

Note: Only part of the references are listed.

Article Infectious Diseases

A computational study of the interface interaction between SARS-CoV-2 RBD and ACE2 from human, cat, dog, and ferret

William O. Sote et al.

Summary: A study on the interactions between SARS-CoV-2 spike glycoprotein and ACE2 in cats, dogs, and ferrets revealed significant differences in interacting residues between different animal species, which can aid in choosing appropriate animal models for studying the pathology of COVID-19.

TRANSBOUNDARY AND EMERGING DISEASES (2022)

Add to Collection

Article Microbiology

Effects of Spike Mutations in SARS-CoV-2 Variants of Concern on Human or Animal ACE2-Mediated Virus Entry and Neutralization

Yunjeong Kim et al.

Summary: This study reveals the host range of SARS-CoV-2 and the effects of recently emergent S protein substitutions on viral entry, virus replication, and antibody-mediated viral neutralization, with particular emphasis on the significant impact of substitutions in the S protein of the Omicron variant on antibody neutralization.

MICROBIOLOGY SPECTRUM (2022)

Add to Collection

Article Biology

Interactions of the Receptor Binding Domain of SARS-CoV-2 Variants with hACE2: Insights from Molecular Docking Analysis and Molecular Dynamic Simulation

Ismail Celik et al.

Summary: Since the COVID-19 pandemic began in late 2019, SARS-CoV-2 has continuously evolved, giving rise to multiple variants. Through protein-protein interaction studies, we investigated how five SARS-CoV-2 variants interact with the hACE2 receptor in host cells, finding that these variations impact the binding of the spike protein to hACE2.

BIOLOGY-BASEL (2021)

Add to Collection

Article Infectious Diseases

Receptor utilization of angiotensin-converting enzyme 2 (ACE2) indicates a narrower host range of SARS-CoV-2 than that of SARS-CoV

Qiong Wang et al.

Summary: This study found that SARS-CoV-2 utilizes less ACE2 receptors than SARS-CoV, showing a narrower host range and a tendency to not use murine or non-mammal ACE2 receptors. Additionally, pangolin-CoV is more similar in ACE2 utilization profile to SARS-CoV than to SARS-CoV-2. Further in vivo studies are needed to verify the actual susceptibility of these animals to coronaviruses. The comparison of amino acid sequences of ACE2 receptors revealed potentially critical residues determining the varying receptor utilization of SARS-CoV, SARS-CoV-2, and pangolin-CoV. This research enhances understanding of the receptor utilization of pandemic coronaviruses, aiding in virus tracing, intermediate host screening, and epidemic prevention for pathogenic coronaviruses.

TRANSBOUNDARY AND EMERGING DISEASES (2021)

Add to Collection

Article Veterinary Sciences

Predicting susceptibility for SARS-CoV-2 infection in domestic and wildlife animals using ACE2 protein sequence homology

Ashutosh Kumar et al.

Summary: The article introduces a bioinformatics based method for predicting susceptibility to SARS-CoV-2 infection in domestic and wildlife animals, providing a screening tool for guiding viral RNA testing for animals at risk of COVID-19.

ZOO BIOLOGY (2021)

Add to Collection

Article Biochemical Research Methods

Key residues influencing binding affinities of 2019-nCoV with ACE2 in different species

Senbiao Fang et al.

Summary: The research reveals the potential of cross-species infections by the new coronavirus as well as the binding abilities of ACE2 proteins from different species. While 21 species show capabilities to bind with the novel coronavirus, some species like bat, pig, and dog exhibit significant improvements in binding affinities compared to human beings. This research may provide valuable insights for future epidemic detection, drug and vaccine development, and global eco-system protections.

BRIEFINGS IN BIOINFORMATICS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Research Article Diversity of ACE2 and its interaction with SARS-CoV-2 receptor binding domain

Jessie Low-Gan et al.

Summary: This study investigated the binding affinity between ACE2 proteins from different animal species and SARS-CoV-2. Results showed that human and hamster ACE2 had the strongest binding affinity, while horseshoe bat and ferret ACE2 had weaker binding activity. The findings offer insights into understanding ACE2-RBD binding and virus tropism.

BIOCHEMICAL JOURNAL (2021)

Add to Collection

Editorial Material Microbiology

Zooanthroponotic potential of SARS-CoV-2 and implications of reintroduction into human populations

Arinjay Banerjee et al.

Summary: The emergence of new variants of SARS-CoV-2 due to continuous adaptations in humans and transmission between humans and animals has raised concerns about the efficacy of vaccines. Understanding the human-to-animal transmission of SARS-CoV-2 and its implications is important for studying the persistence of the virus in animals and vaccine-mediated immunity.

CELL HOST & MICROBE (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Evaluating angiotensin-converting enzyme 2-mediated SARS-CoV-2 entry across species

Hong-Liang Zhang et al.

Summary: The study found that ACE2 receptors of various animal species, including Chinese horseshoe bats, domestic cats, dogs, wild pigs, goats, and pangolins, can mediate the entry of SARS-CoV-2 into non-susceptible cells. These results clarify that SARS-CoV-2 can utilize ACE2 receptors of multiple animal species, making the tracking of natural reservoirs and intermediate hosts complex.

JOURNAL OF BIOLOGICAL CHEMISTRY (2021)

Add to Collection

Article Biochemical Research Methods

Which species does the virus like most: Binding modes study between SARS-CoV-2 S protein and ACE2 receptor

Sheng Guo et al.

Summary: The study found that the binding free energies of S protein with ACE2 from Procyon lotor and Camelus dromedarius are comparable to that of humans, indicating they may potentially serve as hosts for transmitting the virus to humans.

JOURNAL OF MOLECULAR GRAPHICS & MODELLING (2021)

Add to Collection

Article Multidisciplinary Sciences

Functional and genetic analysis of viral receptor ACE2 orthologs reveals a broad potential host range of SARS-CoV-2

Yinghui Liu et al.

Summary: Epidemiological studies have shown that bats are the natural reservoir of SARS-CoV-2, but the host range and intermediate hosts for transmission are unknown. This study characterized the ability of ACE2 from various species to support viral entry, suggesting a potentially broad host tropism of SARS-CoV-2. Analysis of ACE2 orthologs revealed that New World monkey ACE2 could not support viral entry, with genetic determinants restricting this interaction.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Add to Collection

Article Virology

Application of Environment-Friendly Rhamnolipids against Transmission of Enveloped Viruses Like SARS-CoV2

Ling Jin et al.

Summary: In the face of new emerging respiratory viruses such as SARS-CoV2, non-pharmaceutical interventions like mask-wearing and social distancing are not enough to prevent the spread. Research shows that using rhamnolipid 222B coated on masks or plastic surfaces can effectively reduce the transmission of respiratory viruses.

VIRUSES-BASEL (2021)

Add to Collection

Article Multidisciplinary Sciences

Predicting mammalian hosts in which novel coronaviruses can be generated

Maya Wardeh et al.

Summary: The study utilized a machine learning approach to predict associations between mammals and multiple coronaviruses, estimating the potential for novel coronavirus generation through recombination. It demonstrated a significant underestimation of the scale of novel coronavirus generation in wild and domesticated animals, while also identifying high-risk species for coronavirus surveillance.

NATURE COMMUNICATIONS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

Cell entry by SARS-CoV-2

Ruchao Peng et al.

Summary: SARS-CoV-2 enters host cells by interacting with the ACE2 receptor, leading to fusion between viral and cellular membranes, with involvement of auxiliary receptors and cofactors. Understanding the molecular events during viral entry is crucial for developing vaccines and therapeutics.

TRENDS IN BIOCHEMICAL SCIENCES (2021)

Add to Collection

Article Multidisciplinary Sciences

Cross-neutralizing antibodies bind a SARS-CoV-2 cryptic site and resist circulating variants

Tingting Li et al.

Summary: The study identified two cross-neutralizing antibodies targeting the receptor-binding domain of SARS-CoV-2, which can effectively neutralize various virus variants, providing potential options for public health interventions.

NATURE COMMUNICATIONS (2021)

Add to Collection

Article Genetics & Heredity

SARS CoV-2 Spike Protein in silico Interaction With ACE2 Receptors From Wild and Domestic Species

Santiago Rendon-Marin et al.

Summary: SARS-CoV-2 has been identified as having high interaction potential with domestic cats and wild felids, suggesting they could be potential intermediate hosts or susceptible animals for the virus. Comparative protein-protein molecular docking analysis revealed differentiated susceptibility among animal species, with ACE2 receptors from domestic cats and tigers showing efficient interaction with the spike protein of SARS-CoV-2.

FRONTIERS IN GENETICS (2021)

Add to Collection

Article Microbiology

Zoonotic Risk: One More Good Reason Why Cats Should Be Kept Away from Bats

Valeria B. Salinas-Ramos et al.

Summary: Bats are unfairly blamed for the COVID-19 pandemic, with human impact on the environment and the spread of domestic animals being the real causes. Predation by cats on bats can pose zoonotic risks, potentially leading to the spread of diseases to humans. Efforts should be made to address this threat through research and management strategies.

PATHOGENS (2021)

Add to Collection

Article Virology

ACE2 models of frequently contacted animals provide clues of their SARS-CoV-2 S protein affinity and viral susceptibility

Cheng Ma et al.

Summary: The study found differences in the binding affinities of ACE2 proteins from different species to the SARS-CoV-2 S protein, with humans, gorillas, and monkeys predicted to have the highest affinities while mice and rats have the lowest. This suggests a potential mechanism for the transmission of the virus between animals and humans.

JOURNAL OF MEDICAL VIROLOGY (2021)

Add to Collection

Article Cell Biology

Direct Conjugation of NEDD8 to the N-Terminus of a Model Protein Can Induce Degradation

Kartikeya Vijayasimha et al.

Summary: The study demonstrates that fusion of NEDD8 to a protein of interest leads to rapid degradation, depending on functional ubiquitin-conjugation system. However, the inhibitor of the E1 activating enzyme for NEDD8 failed to prevent degradation of other destabilized substrates.

CELLS (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Binding and molecular basis of the bat coronavirus RaTG13 virus to ACE2 in humans and other species

Kefang Liu et al.

Summary: Research has shown that the SARS-CoV-2 virus may originate from bats, with genetic sequences closely related to RaTG13. Experiments revealed that residue 501 plays a key role in determining the potential host range of RaTG13. Additionally, it was found that SARS-CoV-2 can induce strong cross-reactive antibodies and a monoclonal antibody capable of cross-neutralizing RaTG13.

CELL (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Molecular basis of cross-species ACE2 interactions with SARS-CoV-2-like viruses of pangolin origin

Sheng Niu et al.

Summary: The study found that the RBDs of pangolin coronaviruses can bind to human ACE2, allowing entry of pseudotyped VSV particles into cells expressing ACE2, suggesting potential infectivity of these two pangolin coronaviruses in humans. Additionally, their ACE2 binding modes are similar to SARS-CoV-2, with a broader host range than SARS-CoV-2, indicating the need for further monitoring of pangolin coronaviruses.

EMBO JOURNAL (2021)

Add to Collection

Article Chemistry, Medicinal

ACE2-Variants Indicate Potential SARS-CoV-2-Susceptibility in Animals: A Molecular Dynamics Study

Szymon Pach et al.

Summary: SARS-CoV-2, with spike glycoproteins for binding to host cells' ACE2, has a broad host range including cats, ferrets, and Syrian hamsters but excluding dogs, mice, rats, pigs, and chickens in terms of susceptibility. Researchers developed molecular descriptors to analyze infection models, allowing predictions of species susceptibility.

MOLECULAR INFORMATICS (2021)

Add to Collection

Article Virology

Serological Detection of SARS-CoV-2 Antibodies in Naturally-Infected Mink and Other Experimentally-Infected Animals

Francisco J. Berguido et al.

Summary: The study utilized luciferase immunoprecipitation systems (LIPS) to detect antibodies against SARS-CoV-2 virus in different animal species, demonstrating that the method is suitable for sero-surveillance in a range of animal species, with better performance in the detection of antibodies against the S protein.

VIRUSES-BASEL (2021)

Add to Collection

Article Multidisciplinary Sciences

In silico comparison of SARS-CoV-2 spike protein-ACE2 binding affinities across species and implications for virus origin

Sakshi Piplani et al.

Summary: The study found that the spike protein of SARS-CoV-2 had the highest binding affinity to human ACE2, with pangolin ACE2 showing the next highest despite lower sequence homology and monkey ACE2 having much lower affinity despite high sequence similarity to human ACE2. Species with ACE2 in the upper half of predicted affinity range were found to be permissive to SARS-CoV-2 infection, suggesting a correlation between binding affinity and infection susceptibility. These findings suggest that the early SARS-CoV-2 isolates were well adapted to bind strongly to human ACE2, facilitating efficient human-to-human transmission and demonstrating the usefulness of in silico structural modelling methods in predicting virus behavior and aiding in countermeasure development.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Multidisciplinary Sciences

Predicting hosts based on early SARS-CoV-2 samples and analyzing the 2020 pandemic

Qian Guo et al.

Summary: The DeepHoF deep learning method efficiently predicts host likelihood scores for novel viruses, making reliable predictions, especially for viruses without close phylogenetic neighbors. Through a deep analysis of the host likelihood profile, potential hosts for SARS-CoV-2, including minks, bats, dogs, and cats, were identified. Additionally, a large-scale genome analysis revealed the uniformity of host range among SARS-CoV-2 samples and the strong association of SARS-CoV-2 between humans and minks.

SCIENTIFIC REPORTS (2021)

Add to Collection

Article Multidisciplinary Sciences

A pneumonia outbreak associated with a new coronavirus of probable bat origin

Peng Zhou et al.

NATURE (2020)

Add to Collection

Article Multidisciplinary Sciences

Structural basis for the recognition of SARS-CoV-2 by full-length human ACE2

Renhong Yan et al.

SCIENCE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Structural and Functional Basis of SARS-CoV-2 Entry by Using Human ACE2

Qihui Wang et al.

CELL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Structure, Function, and Antigenicity of the SARS-CoV-2 Spike Glycoprotein

Alexandra C. Walls et al.

CELL (2020)

Add to Collection

Article Biochemistry & Molecular Biology

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann et al.

CELL (2020)

Add to Collection

Article Microbiology

Infection and Rapid Transmission of SARS-CoV-2 in Ferrets

Young-Il Kim et al.

CELL HOST & MICROBE (2020)

Add to Collection

Article Ophthalmology

Expression of SARS-CoV-2 receptor ACE2 and TMPRSS2 in human primary conjunctival and pterygium cell lines and in mouse cornea

Di Ma et al.

EYE (2020)

Add to Collection

Article Multidisciplinary Sciences

Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS-coronavirus 2

Jianzhong Shi et al.

SCIENCE (2020)

Add to Collection

Article Virology

Comparison of Severe Acute Respiratory Syndrome Coronavirus 2 Spike Protein Binding to ACE2 Receptors from Human, Pets, Farm Animals, and Putative Intermediate Hosts

Xiaofeng Zhai et al.

JOURNAL OF VIROLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor

Jun Lan et al.

NATURE (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Interaction of the spike protein RBD from SARS-CoV-2 with ACE2: Similarity with SARS-CoV, hot-spot analysis and effect of the receptor polymorphism

Houcemeddine Othman et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Add to Collection

Article Infectious Diseases

SARS-CoV-2 infection in farmed minks, the Netherlands, April and May 2020

Nadia Oreshkova et al.

EUROSURVEILLANCE (2020)

Add to Collection

Article Virology

Broad and Differential Animal Angiotensin-Converting Enzyme 2 Receptor Usage by SARS-CoV-2

Xuesen Zhao et al.

JOURNAL OF VIROLOGY (2020)

Add to Collection

Article Virology

SARS-CoV-2 and Three Related Coronaviruses Utilize Multipke ACE2 Orthologs and Are Potently Blocked by an Improved ACE2-Ig

Yujun Li et al.

JOURNAL OF VIROLOGY (2020)

Add to Collection

Article Multidisciplinary Sciences

Broad host range of SARS-CoV-2 predicted by comparative and structural analysis of ACE2 in vertebrates

Joana Damas et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Add to Collection

Article Biotechnology & Applied Microbiology

In silicoanalysis of ACE2 orthologues to predict animal host range with high susceptibility to SARS-CoV-2

El Mehdi Bouricha et al.

3 BIOTECH (2020)

Add to Collection

Article Cell Biology

Broad host range of SARS-CoV-2 and the molecular basis for SARS-CoV-2 binding to cat ACE2

Lili Wu et al.

CELL DISCOVERY (2020)

Add to Collection

Article Biochemistry & Molecular Biology

The SARS-CoV-2 Spike protein has a broad tropism for mammalian ACE2 proteins

Carina Conceicao et al.

PLOS BIOLOGY (2020)

Add to Collection

Article Biochemical Research Methods

Insights on cross-species transmission of SARS-CoV-2 from structural modeling

Joao P. G. L. M. Rodrigues et al.

PLOS COMPUTATIONAL BIOLOGY (2020)

Add to Collection

Article Biochemical Research Methods

Identifying the Zoonotic Origin of SARS-CoV-2 by Modeling the Binding Affinity between the Spike Receptor-Binding Domain and Host ACE2

Xiaoqiang Huang et al.

JOURNAL OF PROTEOME RESEARCH (2020)

Add to Collection

Article Cell Biology

Characterization of macroautophagic flux in vivo using a leupeptin-based assay

Jeffrey Haspel et al.

AUTOPHAGY (2011)

Add to Collection

Article Virology

A Quantitative Affinity-Profiling System That Reveals Distinct CD4/CCR5 Usage Patterns among Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus Strains

Samantha H. Johnston et al.

JOURNAL OF VIROLOGY (2009)

Add to Collection

Article Virology

Analysis of the genome sequence of an alpaca coronavirus

L. Jin et al.

VIROLOGY (2007)

Add to Collection

Article Virology

The level of CD81 cell surface expression is a key determinant for productive entry of hepatitis C virus into host cells

George Koutsoudakis et al.

JOURNAL OF VIROLOGY (2007)

Add to Collection

Article Virology

West Nile virus discriminates between DC-SIGN and DC-SIGNR for cellular attachment and infection

CW Davis et al.

JOURNAL OF VIROLOGY (2006)

Add to Collection

Article Biochemistry & Molecular Biology

Trans-complementation of vector replication versus Coxsackie-adenovirus-receptor overexpression to improve transgene expression in poorly permissive cancer cells

H Fechner et al.

GENE THERAPY (2000)

Add to Collection

© Peeref 2019-2024. All rights reserved.