Journal
JOURNAL OF VETERINARY INTERNAL MEDICINE
Volume 36, Issue 5, Pages 1733-1741Publisher
WILEY
DOI: 10.1111/jvim.16516
Keywords
ambulation; locomotion; outcome measure; spinal cord injury
Categories
Ask authors/readers for more resources
This study validates a new walking test that provides robust data on ambulatory recovery in dogs with thoracolumbar spinal cord injury, suitable for large-scale pragmatic trials on treatment.
Background Despite its importance, there is no agreed definition of recovery of ambulation in dogs with spinal cord injury. Objectives To validate a new walking test in dogs recovering from thoracolumbar spinal cord injury. Animals Two hundred twenty-four dogs weighing <20 kg: 120 normally ambulatory dogs, plus 104 dogs undergoing decompressive surgery for acute thoracolumbar intervertebral disc herniation. Methods Prospective cohort studies. The distance each freely-ambulatory dog walked during 50 step cycles was regressed on ulna length. For each postsurgical dog, we recorded when the calculated 50-step distance was completed without falling, or their inability to complete this distance by 4 months or more after surgery. Bayesian analysis compared outcomes for presurgical neurologic categories; association of recovery with several preoperative variables was explored using logistic and time-to-event regression. Results For control dogs, 50-step distance (m) = 1.384 x ulnar length (cm) + 2.773. In postsurgical dogs, the 50-step test provided decisive evidence that deep pain-negative dogs were less likely to recover ambulation than dogs with intact pain perception (12/29 recovered vs 71/75; Bayes factor [BF] = 5.9 x 10(6)) and, if they did recover, it took much longer (median 91 days vs median 14 days; BF = 1.5 x 10(3)). Exploratory analysis suggested that presurgical neurologic status (subhazard ratio [SHR] = 0.022; P < .001) and duration of presurgical anesthesia (SHR = 0.740; P = .04) were associated with rapidity of recovery. Conclusions and Clinical Importance This straightforward 50-step walking test provides robust data on ambulatory recovery well-suited to large scale pragmatic trials on treatment of thoracolumbar spinal cord injury in dogs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available