4.4 Article

Percutaneous Sclerotherapy for Budd-Chiari Syndrome Secondary to Giant Hepatic Venous Malformations (Hemangiomas)

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ELSEVIER SCIENCE INC
DOI: 10.1016/j.jvir.2022.05.022

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This study confirmed the safety and effectiveness of percutaneous sclerotherapy in the treatment of secondary Budd-Chiari syndrome caused by hepatic venous malformations. Symptoms significantly improved after treatment, with a reduction in lesion volume and an increase in IVC luminal area.
This prospective study evaluated the safety and effectiveness of percutaneous sclerotherapy in the treatment of secondary Budd-Chiari syndrome due to hepatic venous malformations (HVMs). Four patients (mean age, 40 years; 3 women) with 5 HVMs underwent 7 sessions of percutaneous sclerotherapy with a mixture of bleomycin and lipiodol. All patients had chronic Budd-Chiari syndrome, determined based on imaging findings, with the main symptom being abdominal discomfort and distention. On physical examination, 2 patients had ascites and the other 2 had an epigastric mass. The indication for treatment was intractable abdominal symptoms due to hepatic and/or inferior vena cava (IVC) outflow compression. All procedures were technically successful, with no major complications. Three patients underwent a second session because of incomplete IVC decompression. The patients' symptoms completely resolved at 6 and 12 months of follow-up. There was a significant reduction in lesion volume (P=.007) and an increase in IVC luminal area (P=.018) at 12 months of follow-up.

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