Journal
JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE
Volume 16, Issue 12, Pages 1061-1068Publisher
WILEY
DOI: 10.1002/term.3355
Keywords
molecular engineering; myogenic differentiation; regenerative medicine; satellite cells; skeletal muscle; stem cells; tissue engineering
Categories
Funding
- National Science Foundation [1659244]
- American Heart Association [20PRE35211108]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1659244] Funding Source: National Science Foundation
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Skeletal muscle tissue engineering has been a focus in developing regenerative strategies for injured or degenerative skeletal muscle tissue. Stem cells have gained attention as potential sources for developing skeletal muscle tissue. Understanding the molecular pathways that govern skeletal muscle formation in development is key to advancing stem cell differentiation.
Skeletal muscle tissue engineering has been a key area of focus over the years and has been of interest for developing regenerative strategies for injured or degenerative skeletal muscle tissue. Stem cells have gained increased attention as sources for developing skeletal muscle tissue for subsequent studies or potential treatments. Focus has been placed on understanding the molecular pathways that govern skeletal muscle formation in development to advance differentiation of stem cells towards skeletal muscle fates in vitro. Use of growth factors and transcription factors have long been the method for guiding skeletal muscle differentiation in vitro. However, further research in small molecule induced differentiation offers a xeno-free option that could result from use of animal derived factors.
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