Journal
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
Volume 133, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.jmbbm.2022.105324
Keywords
Glass-ionomer cement; Diatomaceous earth; Drug-loaded agent; Natural material; Drug delivery
Funding
- FNP [POIR.04.04.00-00-1792/18-00]
- European Union under the European Regional Development Fund
- Department of Materials Science and Production, Faculty of Mechanical Engineering, Bialystok University of Technology, Poland [WZ/WM-IIM/2/2020]
Ask authors/readers for more resources
The effect of introducing diatomaceous earth as a filler in a glass-ionomer cement matrix was investigated. The results showed that diatomaceous earth particles are uniformly distributed in the matrix and can enhance surface microhardness and roughness, but have no effect on wear performance or compressive strength.
The effect of a natural filler (diatomaceous earth [DE], a promising drug-delivery agent) and its content was investigated on the performance of a model glass-ionomer cement (GIC). Three sample series, differing in DE content (0, 2.5 and 5 wt%), were prepared using a commercial GIC as a matrix (3M Ketac Molar Easymix). The resultant surface microhardness and roughness, wear performance, and compressive strength of the samples were measured after the samples had been stored in deionized water at 37 degrees C for a fixed time. Moreover, the film thickness was tested for the freshly mixed samples. The numerical data was subjected to statistical analysis, in order to test the null hypotheses of the equality of the measured properties between the reference and the DE-modified samples. According to the results, diatomaceous earth particles are uniformly distributed in the GIC matrix, and the cavities of frustules tend to be filled with the GIC. This translates into the observed performance of the DE-loaded GIC. Compared with the reference material (0 wt% DE), the surface microhardness (2.5 wt% DE, p = 0.014; 5 wt% DE, p = 0.005) and roughness (e.g. Ra; 2.5 wt% DE, p = 0.003; 5 wt% DE, p < 0.001) are increased. No effect on the wear performance (p = 0.530 and 0.256, respectively) or compressive strength (p = 0.514) was noticed in the case of DE partially substituting the glass phase. Based on the study results, it is evidenced that diatom frustules are a suitable filler for application in conventional glass-ionomer cements as the glass-substituting drug-loaded carrier. Notably, however, the surface finish method of the DE-filled materials needs development.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available