Microwave irradiation for the synthesis of quinoline scaffolds: a review

This review article provides a detailed overview of the microwave-assisted synthesis of quinoline and its derivatives. Traditional synthetic techniques require the utilisation of costly and severe conditions, such as high temperatures and low yielding. Nowadays, researchers are looking for innovative ways to decrease the usage of chemicals and solvents which are harmful to both human health and the environment. The green pathway for the synthesis of quinoline derivatives was described in this review article, and it was proven to be significantly more effective than traditional methods. These techniques can be implemented to industries to increase atom economy. This article contains essential microwave irradiation synthesis methods for quinoline and its derivatives using that are pollution-free, energy-efficient, less time-consuming, solid supported, one pot reaction, solvent free reaction condition, ultrasound promoted synthesis, photocatalytic synthesis (UV radiations) and ionic liquids. Quinoline and its derivatives are frequently used in the pharmaceutical industry.

Automated summary

This review provides a detailed overview of microwave-assisted synthesis of quinoline and its derivatives. The importance of environmentally friendly synthesis methods is emphasized, and the results show that microwave irradiation synthesis is more efficient than traditional methods. These techniques have the advantages of pollution-free, energy-efficient, and time-saving, and can be applied in industrial production.