Detection of the Neurodegenerative Drug in a Biological Sample Using Three-Dimensional Sphere Mixed Metal Oxide Tailored with Carbon Fiber as an Electrocatalyst by Voltammetry Technique

The scientific community has shown a lot of interest in the design and engineering of electrodes as sensing platforms for sensitive and selective drug detection in recent years. The sensor based on three-dimensional spheres like NiCo(2)O4 tailored on carbon nanofiber CNF as a hybrid composite was prepared by hydrothermal-assisted synthesis. This combination was preferred due to its superior electro-catalytic activity. Various physical characterizations, such as morphological analysis and spectroscopic tests, were performed on the as-synthesized composite. The electrochemical performance of the modified NCO@CNE electrode is investigated for the detection of clioquinol. The structural property of NCO@CNE promoted a high charge transfer ratio with outstanding conductivity. Upon the amperometric analysis, a low detection limit (LOD) of 8 nM with a very wide linear range of 0.01-301.4 mu M and good sensitivity of 0.177 mu A mu M-1 cm(-2) was witnessed for clioquinol detection. Additionally, NCO @CNF modified electrode demonstrated superior anti-interference capability, repeatability, reproducibility, cycle stability (30 cycles) and operational stability (2000 s). The proposed NCO@CNE electrode was tested with diverse biological samples like human blood and urine and showed remarkable recovery. (C) 2022 The Electrochemical Society (ECS). Published on behalf of ECS by IOP Publishing Limited.

Automated summary

The scientific community has shown great interest in the design and engineering of electrodes as sensing platforms for sensitive and selective drug detection. This study investigates a sensor based on a hybrid composite of NiCo(2)O4 and carbon nanofiber for the detection of clioquinol. The modified NCO@CNE electrode demonstrates high charge transfer ratio, wide linear range, and good sensitivity for clioquinol detection, as well as superior anti-interference capability and stability. The proposed electrode also shows remarkable recovery in diverse biological samples.