Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume -, Issue -, Pages -Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.2c08304
Keywords
-
Categories
Funding
- European Research Council [639594]
- Leverhulme Trust (Philip Leverhulme Prize)
- EPSRC [EP/N509619/1]
- University of Liverpool
- European Research Council (ERC) [639594] Funding Source: European Research Council (ERC)
Ask authors/readers for more resources
Unique examples of aza-Heck-based C(sp3)-H functionalization cascades are described, where alkyl-Pd(II) intermediates generated from the aza-Heck-type cyclization of N-(pentafluorobenzoyloxy)carbamates undergo C(sp(3))-H palladation to form cyclopropanes. The key factors controlling the site selectivity of the cyclopropanation process have been elucidated, enabling selective access to a wide range of ring- or spiro-fused systems.
Unique examples of aza-Heck-based C(sp3)-H functionalization cascades are described. Under Pd(0)-catalyzed conditions, the aza-Heck-type cyclization of N-(pentafluorobenzoyloxy)carbamates generates alkyl-Pd(II) intermediates that effect C(sp(3))-H palladation en route to cyclopropanes. Key factors that control the site selectivity of the cyclopropanation process have been elucidated such that selective access to a wide range of ring-or spiro-fused systems can be achieved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available
Share Paper
