Journal
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
Volume -, Issue -, Pages -Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jacs.2c06934
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Funding
- National Natural Science Foundation of China [31521004, 21672011, 21822101]
- Lige-Zhaoning Youth Research Fund for Life Sciences, Ministry of Science and Technology [2017YFA0104000]
- College of Chemistry and Molecular Engineering, Peking University
- Peking Tsinghua Center for Life Sciences
- Beijing National Laboratory for Molecular Sciences
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A new and enantioselective total synthesis of the diterpenoid (+)-mutilin is described, which involves the Claisen rearrangement, transannular [2+2] photocycloaddition, ring-opening reaction, and subsequent late-stage alkylations and reduction to forge the characteristic skeleton.
A new and enantioselective total synthesis of the diterpenoid (+)-mutilin is described. Following a Claisen rearrangement approach to construct the 6,9-bicycle, a transannular [2+2] photocycloaddition and the ensuing ring-opening reaction were implemented to forge the characteristic 5-6-8 propellane-like skeleton. Subsequent late-stage alkylations and reduction completed the synthesis.
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