Vitamin D Receptor Gene BSMI, FOKI, APAI, and TAQI Polymorphisms and the Risk of Atopic Dermatitis

Background and Objective: The association between vitamin D receptor (VDR) gene polymorphisms and the risk of skin diseases has been widely studied, yet there is only one study on atopic dermatitis. In this study, we aimed to investigate the association between 4 VDR polymorphisms and atopic dermatitis. Patients and Methods: This cross-sectional case control study was performed between March 2013 and April 2014 at the University Hospital in canakkale, Turkey. Peripheral blood samples were collected in EDTA tubes. DNA extraction was performed using the spin column procedure. The VDR polymorphisms Fokl (rs2228570), Bsml (rs1544410), Apal (rs7975232), and Taql (rs731236) were determined by polymerase chain reaction-restriction fragment length polymorphism analysis in 42 atopic dermatitis patients and 96 healthy individuals from a Turkish population. Results: The VDR rs1544410 polymorphism increased the risk of atopic dermatitis in our Turkish population [OR, 12.2; 95%CI, 0.44-336; P=.05]. The Foql, Taql, and Apal polymorphisms were not significantly associated with atopic dermatitis susceptibility. Conclusion: The VDR Fok1, Taql, and Apal gene polymorphisms were not associated with the risk of atopic dermatitis in the Turkish population but the Bsml polymorphism was found to increase risk.